发明授权
US09120800B2 Process for the preparation of oxymorphone alkaloid and oxymorphone salts
有权
羟吗啡酮生物碱和羟吗啡酮盐的制备方法
- 专利标题： Process for the preparation of oxymorphone alkaloid and oxymorphone salts
- 专利标题（中）： 羟吗啡酮生物碱和羟吗啡酮盐的制备方法
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申请号： US14173314申请日： 2014-02-05
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公开(公告)号： US09120800B2公开(公告)日： 2015-09-01
- 发明人: Ewart Grant , Brian Heinrich , Saroop Matharu , Nicolas Archer
- 申请人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY
- 申请人地址： GB London
- 专利权人： Johnson Matthey Public Limited Company
- 当前专利权人： Johnson Matthey Public Limited Company
- 当前专利权人地址： GB London
- 主分类号： C07D489/08
- IPC分类号： C07D489/08 ; C07D489/02
摘要：
The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6α-oxymorphol produced is ≦3.00 area % as determined by HPLC.
公开/授权文献
- US20150038715A1 PROCESS 公开/授权日：2015-02-05
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