发明授权
- 专利标题： Saccharide conjugates
- 专利标题（中）： 糖共轭物
-
申请号： US14112830申请日： 2012-04-18
-
公开(公告)号： US09120838B2公开(公告)日： 2015-09-01
- 发明人: Alexei Demchenko , Michael R. Nichols , Sophon Kaeothip
- 申请人： Alexei Demchenko , Michael R. Nichols , Sophon Kaeothip
- 申请人地址： US MO Columbia
- 专利权人： Curators of the University of Missouri
- 当前专利权人： Curators of the University of Missouri
- 当前专利权人地址： US MO Columbia
- 代理机构： Haukaas Fish PLLC
- 代理商 Michael H. Haukaas
- 国际申请： PCT/US2012/034064 WO 20120418
- 国际公布： WO2012/145392 WO 20121026
- 主分类号： C07H15/04
- IPC分类号： C07H15/04 ; A61K9/00 ; A61K47/06 ; A61K47/12 ; A61K9/06 ; A61K47/32 ; A61K47/38 ; A61K9/20 ; A61K47/02 ; A61K47/10 ; A61K9/48
摘要：
The invention provides a series of novel Lipid A analogs that are structually simple, synthetically accessible, and capable of blocking the cellular receptor within the signal transduction pathway. The novel Lipid A analogs can include a monosaccharide core with hydrophobic side chains and amino acid ionic motif. The invention further provides methods of using the compounds and compositions thereof in various therapeutic methods.
公开/授权文献
- US20140066390A1 SACCHARIDE CONJUGATES 公开/授权日：2014-03-06