发明授权
- 专利标题： Anti-human P-cadherin (CDH3) recombinant antibody
- 专利标题（中）： 抗人P-钙粘蛋白（CDH3）重组抗体
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申请号： US14129049申请日： 2012-06-19
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公开(公告)号： US09127061B2公开(公告)日： 2015-09-08
- 发明人: Lilin Zhang , Katsuyuki Mitomo , Katsushi Kouda , Yoko Kayukawa
- 申请人： Lilin Zhang , Katsuyuki Mitomo , Katsushi Kouda , Yoko Kayukawa
- 申请人地址： JP Tokyo
- 专利权人： PERSEUS PROTEOMICS INC.
- 当前专利权人： PERSEUS PROTEOMICS INC.
- 当前专利权人地址： JP Tokyo
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： JP2011-140407 20110624; JP2012-084622 20120403
- 国际申请： PCT/JP2012/065620 WO 20120619
- 国际公布： WO2012/176765 WO 20121227
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/28 ; C07K16/46 ; C12N5/10 ; C12N15/09 ; G01N33/53
摘要：
It is an object to provide a recombinant antibody that is an anti-CDH3 antibody having cytotoxicity on CDH3-expressing cells, which is anticipated to have fewer side effects than antibodies derived from animals other than humans and to maintain its therapeutic effects for a long period of time. The present invention provides a recombinant antibody which specifically reacts with an epitope existing in the amino acids at positions 108 to 131 or at positions 551 to 654 of the amino acid sequence shown in SEQ ID NO: 38 that is the extracellular region of human CDH3, and has cytotoxicity against CDH3-expressing cells.
公开/授权文献
- US20140221620A1 ANTI-HUMAN P-CADHERIN (CDH3) RECOMBINANT ANTIBODY 公开/授权日：2014-08-07
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