A system and method for direct memory access (DMA) operation provides for receiving DMA requestors, assigning the received DMA requestors to one or more of a plurality of DMA engines for processing the received DMA requestors, and if one of the received DMA requestors is a safety requestor, assigning the safety requestor to at least two DMA engines of the plurality of DMA engines for processing the safety requestor, disabling a bus interface for coupling at least one DMA engine of the at least two DMA engines to memories, comparing the outputs of the at least two DMA engines, and generating an error message if the comparison of the outputs of the at least two DMA engines are different from each other.