To solve the problems with the prior art that a multi-microphone array cannot inhibit broad-band noises well and cannot be used in the increasingly widespread broad-band communication, embodiments of the present invention disclose a method, a device and a system for eliminating noises with multi-microphone array. The method according to an embodiment of the present invention comprises according to the number of different spacings between each of pairs of microphones of the multi-microphone array, dividing a full frequency band into the same number of sub-bands; decomposing signals of each of the pairs of microphones with the different spacings into a corresponding one of the sub-bands, wherein the larger the spacing between each pair of microphones is, the lower the frequencies of the sub-band into which the signals of the pair of microphones are decomposed will be; adaptively reducing the noises in the decomposed signals of each of the pairs of microphones with the different spacings in the corresponding sub-band to obtain noise-reduced signals for each of the sub-bands; and synthesizing the noise-reduced signals of each of the sub-bands to obtain a signal in which the noises have been reduced with the multi-microphone array in the full frequency band. The embodiments of the present invention can be used in scenarios of hands-free video calls.