Invention Grant
- Patent Title: Fluoroalkyl-1,4-benzodiazepinone compounds
- Patent Title (中): 氟烷基-1,4-苯并二氮杂酮化合物
-
Application No.: US14429941Application Date: 2013-09-20
-
Publication No.: US09133139B2Publication Date: 2015-09-15
- Inventor: Ashvinikumar V. Gavai , Weifang Shan , James Aaron Balog , Claude A. Quesnelle , Wen-Ching Han , George V. DeLucca , Daniel O'Malley , Brian E. Fink
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- International Application: PCT/US2013/060833 WO 20130920
- International Announcement: WO2014/047392 WO 20140327
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D401/04 ; C07D401/12 ; C07D413/12 ; C07D243/24 ; A61K31/5513 ; C07D491/056 ; A61K45/06

Abstract:
Disclosed are compounds of Formula (I): wherein: R2 is phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, or pyridinyl; R3 is H, CH3, CH2(cyclopropyl), pyridinyl, chloropyridinyl, or methoxypyridinyl: and Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Public/Granted literature
- US20150218111A1 FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS Public/Granted day:2015-08-06
Information query