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公开(公告)号：US12145927B2
公开(公告)日：2024-11-19
申请号：US17261968
申请日：2019-07-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Steven P. Seitz , Jay A. Markwalder , David K. Williams , Weifang Shan , Susheel Jethanand Nara , Saumya Roy , Srinivas Cheruku , Nagalakshmi Pulicharla
IPC: C07D405/14 , C07D307/79 , C07D313/08 , C07D405/10 , C07D413/10 , C07D413/14 , C07D417/14 , C07K16/28
Abstract: The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号：US10696648B2
公开(公告)日：2020-06-30
申请号：US16098239
申请日：2017-05-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： David K. Williams , Weifang Shan , James Aaron Balog
IPC: C07D401/10 , C07C275/30 , C07C275/36 , C07C275/34 , C07C275/28 , C07C275/42 , C07C275/26 , A61P35/00 , A61K31/4709 , A61K31/47 , A61K31/277 , A61K31/17 , C07D401/04 , C07D215/18 , C07C275/32
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20180079712A1
公开(公告)日：2018-03-22
申请号：US15564146
申请日：2016-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Audris Huang , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: C07C229/42 , C07C275/42 , C07D295/155 , C07D239/47 , C07D277/64 , C07D335/02 , C07D409/12 , C07D309/14 , C07D405/12 , C07D211/14 , C07D401/12 , C07D317/46 , C07D239/34 , C07D413/12 , C07D265/30 , C07C233/81 , C07D405/14 , C07D207/12 , C07D487/08 , C07D487/04 , C07D471/08 , C07D265/36 , C07D413/14
Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20160289171A1
公开(公告)日：2016-10-06
申请号：US15088211
申请日：2016-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Weiwei Guo , Audris Huang , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Natesan Murugesan , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: C07C229/42 , A61K31/196 , C07D239/47 , A61K31/505 , C07C255/58 , A61K31/277 , C07C275/40 , A61K31/17 , C07D295/155 , A61K31/5375 , C07D277/64 , A61K31/428 , C07D335/02 , A61K31/382 , C07D409/12 , A61K31/506 , C07D309/04 , A61K31/351 , C07D405/12 , C07D211/14 , A61K31/445 , C07D401/12 , C07D413/12 , A61K31/5377 , C07D405/14 , C07D417/12 , C07D487/04 , A61K31/519 , A61K31/501 , C07D471/04 , A61K31/437 , C07D205/04 , A61K31/397 , A61K31/538 , C07D265/36 , A61K39/395
CPC classification number: C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07C229/42 , C07C233/81 , C07C235/38 , C07C235/56 , C07C255/57 , C07C255/58 , C07C275/30 , C07C275/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/08 , C07D211/14 , C07D239/34 , C07D239/47 , C07D265/30 , C07D265/36 , C07D277/64 , C07D295/155 , C07D307/22 , C07D309/04 , C07D309/14 , C07D317/46 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法，其利用 发明。
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公开(公告)号：US11649212B2
公开(公告)日：2023-05-16
申请号：US16754171
申请日：2018-10-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Weifang Shan , David K. Williams , Liping Zhang
IPC: C07D215/46 , C07D215/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07K16/28
CPC classification number: C07D215/46 , C07D215/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07K16/2818
Abstract: The present invention provides compounds of formula (I), formula (II) or formula (III), wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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Patent Agency Ranking
公开(公告)号：US11337970B2
公开(公告)日：2022-05-24
申请号：US16328449
申请日：2017-08-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Emily Charlotte Cherney , Weifang Shan , Liping Zhang , Susheel Jethanand Nara , Audris Huang , James Aaron Balog
IPC: A61K31/4709 , A61K31/4375 , A61K31/5025 , A61K31/517 , A61K39/395 , C07D401/08 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/056
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US11066383B2
公开(公告)日：2021-07-20
申请号：US16098245
申请日：2017-05-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： David K. Williams , Weifang Shan , Liping Zhang , Emily Charlotte Cherney , James Aaron Balog
IPC: C07D401/04 , C07D401/06 , C07D215/46 , C07D215/14 , A61P35/00 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/496 , C07D215/18
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20210147383A1
公开(公告)日：2021-05-20
申请号：US16950978
申请日：2020-11-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Andrew P. DEGNAN , Godwin Kwame Kumi , Audris Huang , James Aaron Balog , Ashok Vinayak Purandare , Weifang Shan , Guo Li
IPC: C07D401/14 , C07D405/14 , C07D487/04 , C07D417/14 , C07D498/18
Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: Z is CR6R6 or C═O; Ring A is: and R1, R2, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US12059420B2
公开(公告)日：2024-08-13
申请号：US17261954
申请日：2019-07-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Jay A. Markwalder , Weifang Shan , David K. Williams , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Srinivas Cheruku , Ramesh Kumar Sistla
IPC: A61K31/506 , A61K31/4418 , A61K31/4439 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K39/395 , C07D213/74 , C07D213/75 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D487/04
CPC classification number: A61K31/506 , A61K31/4418 , A61K31/4439 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K39/3955 , C07D213/74 , C07D213/75 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D487/04
Abstract: The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号：US20190002402A1
公开(公告)日：2019-01-03
申请号：US15737798
申请日：2016-06-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Jay A. Markwalder , Weifang Shan , David K. Williams
IPC: C07C275/42 , A61K31/196 , A61K45/06 , C07D239/42 , A61K31/505 , C07D213/72 , A61K31/4406 , C07D261/14 , A61K31/42 , C07D285/135 , A61K31/433 , C07D277/38 , A61K31/426 , C07D263/32 , A61K31/421 , C07D209/08 , A61K31/404 , C07C311/46 , A61K31/18 , C07D333/34 , A61K31/381 , C07D239/47 , A61K31/513 , C07D257/04 , A61K31/41
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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