发明授权
- 专利标题： Methods and compositions for treating and preventing malaria using an invasion ligand directed to a protease-resistant receptor
- 专利标题（中）： 使用针对蛋白酶抗性受体的入侵配体治疗和预防疟疾的方法和组合物
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申请号： US13061146申请日： 2009-08-27
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公开(公告)号： US09134311B2公开(公告)日： 2015-09-15
- 发明人: Alan Cowman , Lin Chen , Jacob Baum
- 申请人： Alan Cowman , Lin Chen , Jacob Baum
- 申请人地址： AU Parkville, Victoria
- 专利权人： Walter and Eliza Hall Institute of Medical Research
- 当前专利权人： Walter and Eliza Hall Institute of Medical Research
- 当前专利权人地址： AU Parkville, Victoria
- 代理机构： Klauber & Jackson LLC
- 国际申请： PCT/AU2009/001099 WO 20090827
- 国际公布： WO2010/022452 WO 20100304
- 主分类号： A61K39/015
- IPC分类号： A61K39/015 ; G01N33/569 ; A61K39/02 ; C07K14/445 ; A61K39/00
摘要：
This invention relates to an immunogenic molecule comprising a contiguous amino acid sequence of an invasion ligand of a strain of Plasmodium falciparum, the invasion ligand capable of binding to an erythrocyte receptor, the receptor function being resistant to trypsin and neuraminidase and chymotrypsin, wherein when administered to a subject the molecule is capable of inducing an immune response to the strain. The invention further relates to compositions and methods for the treatment of diseases such as malaria.
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