公开(公告)号：US10202430B2

公开(公告)日：2019-02-12

申请号：US12738774

申请日：2008-10-17

申请人： Larry R. Pease ,  Moses Rodriguez

发明人： Larry R. Pease ,  Moses Rodriguez

IPC分类号： A61K39/00 ,  C07K14/47

摘要： Materials and methods for using multivalent molecules (e.g., antibodies) to modulate cellular function. A molecule can be targeted to a particular type of cell, either through direct binding to an epitope on the surface of the cell, or through a linker that recognizes both the multivalent molecule and a marker on the cell surface. The invention provides a chimeric polypeptide comprising a first amino acid sequence and a second amino acid sequence, wherein the first amino acid sequence comprises an WIC Class I peptide sequence, and where the second amino acid sequence comprises an epitope to which a multivalent molecule binds, including wherein the multivalent molecule is an IgM antibody, including antibody hIgM22. The invention provides a linker molecule for targeting IgM antibody, including antibody hIgM22, to a cell in the oligodendrocyte lineage.

公开(公告)号：USD838658S1

公开(公告)日：2019-01-22

申请号：US29567030

申请日：2016-06-03

申请人： Jorma Tikka ,  Niko Nummi ,  Tomi Korkama

设计人： Jorma Tikka ,  Niko Nummi ,  Tomi Korkama

公开(公告)号：US10131586B2

公开(公告)日：2018-11-20

申请号：US14906024

申请日：2014-07-22

申请人： AB7 INNOVATION S.A.S.U.

发明人： Rene Chelle ,  Urbain Makoumbou

IPC分类号： C05F11/08 ,  C05G3/00 ,  C12N1/04 ,  C12N1/14 ,  C12N1/20 ,  C12N1/22 ,  C12N11/02 ,  C12N11/10 ,  C12N11/12

摘要： The invention relates to a solid inoculum carried in a superabsorbent agro-pellet with a variable volume, operating in a natural mini fermenter preloaded with an anhydrous nutritive medium, encouraging rapid regrowth of the viable micro-organisms and the continuous multiplication thereof. The liquid inoculum incorporated into the carrier at a low density of microbial cells is preferably comprised between 1/500e and 1/10e of the density recommended by the norm for a liquid inoculum of the same strain. The bioaugmentation of the microbial population is between 104 and 106 additional microbial cells. The solid inoculum according to the invention allows the preservation of the microorganisms and the handling thereof in advantageous conditions. It is not exposed to soil leaching caused by water. Said inoculum is used for the biological treatment of crops for the development and/or the preservation thereof from parasite attacks.

公开(公告)号：USD832465S1

公开(公告)日：2018-10-30

申请号：US29597158

申请日：2017-03-14

申请人： Esa Hilliaho

设计人： Esa Hilliaho

公开(公告)号：US10053681B2

公开(公告)日：2018-08-21

申请号：US14480822

申请日：2014-09-09

申请人： The Rockefeller University

发明人： Vincent A. Fischetti ,  Anu Daniel ,  Chad Euler

IPC分类号： C12N9/36 ,  A01N63/00 ,  C07K14/005 ,  A61K38/00 ,  A61K38/47

CPC分类号： C12N9/2462 ,  A01N63/00 ,  A61K38/00 ,  A61K38/47 ,  C07K14/005 ,  C07K2319/00 ,  C12N2795/10322

摘要： The present disclosure relates to chimeric bacteriophage lysins useful for the identification and/or reduction of staphylococcal populations. For example, a chimeric bacteriophage lysin was engineered and shown to effectively kill all strains of staphylococci tested including antibiotic resistant methicillin-resistant S. Aureus and VISA.

公开(公告)号：USD825439S1

公开(公告)日：2018-08-14

申请号：US29597189

申请日：2017-03-15

申请人： Jorma Tikka ,  Tomi Korkama ,  Niko Haanketo

设计人： Jorma Tikka ,  Tomi Korkama ,  Niko Haanketo

公开(公告)号：USD816131S1

公开(公告)日：2018-04-24

申请号：US29596381

申请日：2017-03-08

申请人： Kjell Nymark

设计人： Kjell Nymark

公开(公告)号：US09938321B2

公开(公告)日：2018-04-10

申请号：US14208235

申请日：2014-03-13

申请人： Kent Kirshenbaum ,  Mia L. Huang

发明人： Kent Kirshenbaum ,  Mia L. Huang

IPC分类号： A61K38/12 ,  C07K7/64

CPC分类号： C07K7/64 ,  A61K38/12 ,  Y02A50/463 ,  Y02A50/475 ,  Y02A50/483

摘要： Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: wherein R1 and n are as described herein. The peptoids demonstrate antimicrobial and antimalarial activity and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals including humans where microbial or malarial infection is involved. The present cyclic peptoids are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.

公开(公告)号：US09914915B2

公开(公告)日：2018-03-13

申请号：US14685696

申请日：2015-04-14

申请人： Vincent A. Fischetti ,  Jonathan Schmitz ,  Daniel Gilmer ,  Chad Euler

发明人： Vincent A. Fischetti ,  Jonathan Schmitz ,  Daniel Gilmer ,  Chad Euler

IPC分类号： A61K38/00 ,  A61K9/14 ,  A61K9/06 ,  C12N9/14 ,  C12N9/36 ,  A61K38/16 ,  A61K38/50 ,  A61K38/47 ,  A61K45/06

CPC分类号： C12N9/2462 ,  A61K38/162 ,  A61K38/47 ,  A61K38/50 ,  A61K45/06 ,  C12Y302/01017

摘要： The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.

公开(公告)号：USD811015S1

公开(公告)日：2018-02-20

申请号：US29522068

申请日：2015-03-27

申请人： Niina Thitz ,  Kati Rissanen

设计人： Niina Thitz ,  Kati Rissanen