Systems and methodologies are described herein that facilitate an asynchronous bus architecture for multi-radio coexistence associated with a wireless device. As described herein, a system of buses operating in an asynchronous manner, combined with optional on-chip and/or other supplemental buses, can be utilized to couple respective radios and/or other related endpoints to a coexistence management platform, thereby facilitating management of coexistence between multiple radios in a unified and scalable manner. As further described herein, communication between a coexistence manager and its respective managed endpoints can be facilitated through the use of a single bus or multiple buses that can be switched and/or otherwise operate in a concurrent manner to facilitate expedited conveyance of radio event notifications and their corresponding responses.