Large-dimension MIMO and multipoint broadcasting in new generation of wireless networks create high demand for various types of pilots in transmission signals for channel estimation, data demodulation, synchronization, etc. More pilots, as in existing networks, use more resources and thus diminish the network capacity. Methods and apparatus of heterogeneous pilots are disclosed. A heterogeneous pilot has its own signal characteristics that are different from the primary information-bearing signals in the network. Heterogeneous pilots can be spread-spectrum signals in an OFDM-based wireless network. Heterogeneous pilots use no network resources, and can be as many as desired, and can be designed to have versatile utilities. Also described are methods and apparatus of heterogeneous pilot cancellation that minimizes the interference of heterogeneous pilots on the primary information-bearing signals. Applications of the described methods and apparatus include OFDM-based wireless cellular networks, such as LTE-advanced and Wireless LAN.