Invention Grant
US09139566B2 Fluorine-18 and carbon-11 labeled radioligands for positron emission tomography (PET) imaging for LRRK2
有权
氟-18和碳-11标记的放射性配体用于LRRK2的正电子发射断层扫描（PET）成像
- Patent Title: Fluorine-18 and carbon-11 labeled radioligands for positron emission tomography (PET) imaging for LRRK2
- Patent Title (中): 氟-18和碳-11标记的放射性配体用于LRRK2的正电子发射断层扫描（PET）成像
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Application No.: US13687441Application Date: 2012-11-28
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Publication No.: US09139566B2Publication Date: 2015-09-22
- Inventor: Jan Marik , Zachary Kevin Sweeney , Bryan K. Chan , Anthony Estrada
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Robert C. Hall
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; C07D403/12 ; A61K51/04 ; C07D239/48
Abstract:
A method for positron emission tomography (PET) imaging of LRRK2 in tissue of a subject, the method comprising: administering a compound of formula I, formula II or formula III, or a pharmaceutically acceptable salt thereof to the subject, wherein the compound includes at least one C11 or F18 label thereon; allowing the compound to penetrate into the tissue of the subject; and collecting a PET image of the CNS or brain tissue of the subject.
Public/Granted literature
- US20130156700A1 FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2 Public/Granted day:2013-06-20
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