Invention Grant
- Patent Title: Polynucleotides encoding an intracellular segment of CD40 and a constant region of an immunoglobulin heavy chain
- Patent Title (中): 编码CD40细胞内区段和免疫球蛋白重链恒定区的多核苷酸
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Application No.: US14571425Application Date: 2014-12-16
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Publication No.: US09139639B2Publication Date: 2015-09-22
- Inventor: Ugur Sahin , Ozlem Tureci , Torsten Seppmann , Holger Hoff , Jens Schumacher
- Applicant: BioNTech AG , Universitatsmedizin der Johannes Gutenberg-Universitat Mainz
- Applicant Address: DE DE
- Assignee: BioNTech AG,Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz
- Current Assignee: BioNTech AG,Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz
- Current Assignee Address: DE DE
- Agency: McAndrews, Held & Malloy, Ltd.
- Priority: EP09013690 20091030
- Main IPC: C12N15/12
- IPC: C12N15/12 ; C12N15/11 ; C12N15/63 ; C07K14/705 ; C07K16/00 ; C12N5/0781
Abstract:
The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are—useful for inducing clonal expansion of a B cell having a predetermined antigen-specificity without the need for T cell or CD40L mediated co-stimulation. Thus, the present invention provides tools for clonal expansion of B cells specific for an antigen of interest and the production of B cells secreting antibodies specific for an antigen of interest. The recombinant proteins of the present invention may also be used for generating fully human monoclonal antibodies with a predetermined antigen-specificity from the B cell repertoire of a human subject.
Public/Granted literature
- US20150099302A1 CLONAL EXPANSION OF B CELLS Public/Granted day:2015-04-09
Information query
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