Invention Grant
US09149505B2 Pharmaceutical composition for suppressing angiogenesis, and method for screening active material for suppressing angiogenesis
有权
用于抑制血管发生的药物组合物，以及筛选用于抑制血管发生的活性物质的方法
- Patent Title: Pharmaceutical composition for suppressing angiogenesis, and method for screening active material for suppressing angiogenesis
- Patent Title (中): 用于抑制血管发生的药物组合物，以及筛选用于抑制血管发生的活性物质的方法
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Application No.: US13817738Application Date: 2011-08-18
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Publication No.: US09149505B2Publication Date: 2015-10-06
- Inventor: Yoon Jin Lee , Yun-Sil Lee , Hae-June Lee , Seo-Hyun Choi , Kyeng-Jung Kim
- Applicant: Yoon Jin Lee , Yun-Sil Lee , Hae-June Lee , Seo-Hyun Choi , Kyeng-Jung Kim
- Applicant Address: KR Seoul
- Assignee: Korea Institute of Radiological & Medical Sciences
- Current Assignee: Korea Institute of Radiological & Medical Sciences
- Current Assignee Address: KR Seoul
- Agency: Klarquist Sparkman, LLP
- Priority: KR10-2010-0079858 20100818
- International Application: PCT/KR2011/006066 WO 20110818
- International Announcement: WO2012/023811 WO 20120223
- Main IPC: A61K38/17
- IPC: A61K38/17 ; G01N33/574 ; C07K16/18 ; A61K48/00
Abstract:
The present invention provides a pharmaceutical composition for suppressing angiogenesis, containing heat shock protein 27 (HSP27) or a nucleic acid encoding HSP27. In addition, the present invention provides a pharmaceutical composition for treating cancer, containing HSP27 or a nucleic acid encoding HSP27. Additionally, the present invention provides a method of suppressing the in vitro growth of endothelial cells using HSP27. Further, the present invention provides a method of screening an active material for suppressing angiogenesis or an active material for treating cancer, comprising the following steps: processing endothelial cell lines into samples, respectively; measuring the content of HSP27 in an endothelial cell line; and selecting the sample in which the content of HSP27 in an endothelial cell line is increased compared with a control group.
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