公开(公告)号：US08815243B2

公开(公告)日：2014-08-26

申请号：US13817760

申请日：2011-08-18

申请人： Yoon Jin Lee ,  Yun-Sil Lee ,  Hae-June Lee ,  Seo-Hyun Choi ,  Kyeng-Jung Kim

发明人： Yoon Jin Lee ,  Yun-Sil Lee ,  Hae-June Lee ,  Seo-Hyun Choi ,  Kyeng-Jung Kim

IPC分类号： C07K16/18 ,  C07K14/435 ,  C07K16/44 ,  A61K39/395

CPC分类号： A61K39/3955 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76

摘要： The present invention relates to a pharmaceutical composition for promoting angiogenesis, containing an antibody that specifically binds to heat shock protein (HSP) 27. In addition, the present invention relates to a pharmaceutical composition containing an antibody that specifically binds to HSP 27, for treating an angiogenesis-dependent ailment selected from a group consisting of a wound, chronic ulcer, ischemic stroke, myocardial infarction, angina pectoris, and cerebrovascular dementia. In addition, the present invention relates to a method for promoting the in vitro growth of endothelial cells using an antibody that specifically binds to HSP27. In addition, the present invention relates to a method for screening for active substances for promoting angiogenesis or for active substances for treating an angiogenesis-dependent ailment, the method comprising the following steps: treating vascular endothelial cell lines with each specimen; measuring the content of HSP27 in the respective vascular endothelial cell lines; and selecting a specimen in which the HSP27 content in the vascular endothelial cell lines are decreased as compared to a control group.

摘要翻译： 本发明涉及用于促进血管生成的药物组合物，其含有与热休克蛋白（HSP）27特异性结合的抗体。此外，本发明涉及含有与HSP27特异性结合的抗体的药物组合物，用于治疗 选自伤口，慢性溃疡，缺血性中风，心肌梗死，心绞痛和脑血管性痴呆的血管发生依赖性疾病。 此外，本发明涉及使用特异性结合HSP27的抗体促进内皮细胞体外生长的方法。 此外，本发明涉及一种筛选用于促进血管发生的活性物质的方法或用于治疗血管生成依赖性疾病的活性物质的方法，所述方法包括以下步骤：用每个样品处理血管内皮细胞系; 测量各血管内皮细胞系中HSP27的含量; 并且与对照组相比，选择其中血管内皮细胞系中HSP27含量降低的标本。

公开(公告)号：US20130184336A1

公开(公告)日：2013-07-18

申请号：US13817738

申请日：2011-08-18

申请人： Yoon Jin Lee ,  Yun-Sil Lee ,  Hae-June Lee ,  Seo-Hyun Choi ,  Kyeng-Jung Kim

发明人： Yoon Jin Lee ,  Yun-Sil Lee ,  Hae-June Lee ,  Seo-Hyun Choi ,  Kyeng-Jung Kim

IPC分类号： A61K38/17

CPC分类号： A61K38/1709 ,  A61K48/00 ,  C07K16/18 ,  C07K2317/76 ,  G01N33/57407 ,  G01N33/57484

摘要： The present invention provides a pharmaceutical composition for suppressing angiogenesis, containing heat shock protein 27 (HSP27) or a nucleic acid encoding HSP27. In addition, the present invention provides a pharmaceutical composition for treating cancer, containing HSP27 or a nucleic acid encoding HSP27. Additionally, the present invention provides a method of suppressing the in vitro growth of endothelial cells using HSP27. Further, the present invention provides a method of screening an active material for suppressing angiogenesis or an active material for treating cancer, comprising the following steps: processing endothelial cell lines into samples, respectively; measuring the content of HSP27 in an endothelial cell line; and selecting the sample in which the content of HSP27 in an endothelial cell line is increased compared with a control group.

摘要翻译： 本发明提供了含有热休克蛋白27（HSP27）或编码HSP27的核酸的血管生成抑制药物组合物。 此外，本发明提供了含有HSP27或编码HSP27的核酸的治疗癌症的药物组合物。 此外，本发明提供了使用HSP27抑制内皮细胞的体外生长的方法。 此外，本发明提供了筛选用于抑制血管生成的活性物质或用于治疗癌症的活性物质的方法，包括以下步骤：分别将内皮细胞系分别加工成样品; 测量内皮细胞系中HSP27的含量; 并且与对照组相比，选择其中内皮细胞系中HSP27的含量增加的样品。

公开(公告)号：US09149505B2

公开(公告)日：2015-10-06

申请号：US13817738

申请日：2011-08-18

申请人： Yoon Jin Lee ,  Yun-Sil Lee ,  Hae-June Lee ,  Seo-Hyun Choi ,  Kyeng-Jung Kim

发明人： Yoon Jin Lee ,  Yun-Sil Lee ,  Hae-June Lee ,  Seo-Hyun Choi ,  Kyeng-Jung Kim

IPC分类号： A61K38/17 ,  G01N33/574 ,  C07K16/18 ,  A61K48/00

CPC分类号： A61K38/1709 ,  A61K48/00 ,  C07K16/18 ,  C07K2317/76 ,  G01N33/57407 ,  G01N33/57484

摘要： The present invention provides a pharmaceutical composition for suppressing angiogenesis, containing heat shock protein 27 (HSP27) or a nucleic acid encoding HSP27. In addition, the present invention provides a pharmaceutical composition for treating cancer, containing HSP27 or a nucleic acid encoding HSP27. Additionally, the present invention provides a method of suppressing the in vitro growth of endothelial cells using HSP27. Further, the present invention provides a method of screening an active material for suppressing angiogenesis or an active material for treating cancer, comprising the following steps: processing endothelial cell lines into samples, respectively; measuring the content of HSP27 in an endothelial cell line; and selecting the sample in which the content of HSP27 in an endothelial cell line is increased compared with a control group.

摘要翻译： 本发明提供了含有热休克蛋白27（HSP27）或编码HSP27的核酸的血管生成抑制药物组合物。 此外，本发明提供了含有HSP27或编码HSP27的核酸的治疗癌症的药物组合物。 此外，本发明提供了使用HSP27抑制内皮细胞的体外生长的方法。 此外，本发明提供了筛选用于抑制血管生成的活性物质或用于治疗癌症的活性物质的方法，包括以下步骤：分别将内皮细胞系分别加工成样品; 测量内皮细胞系中HSP27的含量; 并且与对照组相比，选择其中内皮细胞系中HSP27的含量增加的样品。

公开(公告)号：US20130156787A1

公开(公告)日：2013-06-20

申请号：US13817760

申请日：2011-08-18

申请人： Yoon Jin Lee ,  Yun-Sil Lee ,  Hae-June Lee ,  Seo-Hyun Choi ,  Kyeng-Jung Kim

发明人： Yoon Jin Lee ,  Yun-Sil Lee ,  Hae-June Lee ,  Seo-Hyun Choi ,  Kyeng-Jung Kim

IPC分类号： A61K39/395

CPC分类号： A61K39/3955 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76

摘要： The present invention relates to a pharmaceutical composition for promoting angiogenesis, containing an antibody that specifically binds to heat shock protein (HSP) 27. In addition, the present invention relates to a pharmaceutical composition containing an antibody that specifically binds to HSP 27, for treating an angiogenesis-dependent ailment selected from a group consisting of a wound, chronic ulcer, ischemic stroke, myocardial infarction, angina pectoris, and cerebrovascular dementia. In addition, the present invention relates to a method for promoting the in vitro growth of endothelial cells using an antibody that specifically binds to HSP27. In addition, the present invention relates to a method for screening for active substances for promoting angiogenesis or for active substances for treating an angiogenesis-dependent ailment, the method comprising the following steps: treating vascular endothelial cell lines with each specimen; measuring the content of HSP27 in the respective vascular endothelial cell lines; and selecting a specimen in which the HSP27 content in the vascular endothelial cell lines are decreased as compared to a control group.

摘要翻译： 本发明涉及用于促进血管生成的药物组合物，其含有与热休克蛋白（HSP）27特异性结合的抗体。此外，本发明涉及含有与HSP27特异性结合的抗体的药物组合物，用于治疗 选自伤口，慢性溃疡，缺血性中风，心肌梗死，心绞痛和脑血管性痴呆的血管发生依赖性疾病。 此外，本发明涉及使用特异性结合HSP27的抗体促进内皮细胞体外生长的方法。 此外，本发明涉及一种筛选用于促进血管发生的活性物质的方法或用于治疗血管生成依赖性疾病的活性物质的方法，所述方法包括以下步骤：用每个样品处理血管内皮细胞系; 测量各血管内皮细胞系中HSP27的含量; 并且与对照组相比，选择其中血管内皮细胞系中HSP27含量降低的标本。

公开(公告)号：US07049736B2

公开(公告)日：2006-05-23

申请号：US10364653

申请日：2003-02-12

申请人： Hy-yong Suk ,  Guang-Hoon Kim ,  Jong-Uk Kim ,  Chang-Bum Kim ,  Hae-June Lee

发明人： Hy-yong Suk ,  Guang-Hoon Kim ,  Jong-Uk Kim ,  Chang-Bum Kim ,  Hae-June Lee

IPC分类号： H05H1/54

CPC分类号： H05H15/00 ,  G21K1/003

摘要： Background plasma electrons in a laser wake field are trapped and accelerated using a sharp downward density transition. A short and intense laser pulse travels through low density plasma with a sharp downward density transition. The density transition scale length is much smaller than the wavelength of a laser wake wave. As the laser wake wave passes the density transition, its wavelength increases suddenly so that some background plasma electrons are self-injected into the acceleration phase of the wake field and trapped and accelerated by the strong laser wake field.

摘要翻译： 激光尾迹中的背景等离子体电子被捕获并加速使用尖锐的向下的密度转变。 短而强烈的激光脉冲通过低密度等离子体，具有尖锐的向下密度转变。 密度转换刻度长度远小于激光尾波的波长。 随着激光唤醒波通过密度跃迁，其波长突然增加，使得一些背景等离子体电子自我注入到唤醒场的加速阶段，并被强激光尾迹场捕获和加速。