Some implementations disclosed herein provide techniques and arrangements for an specialized logic engine that includes translation lookaside buffer to support multiple threads executing on multiple cores. The translation lookaside buffer enables the specialized logic engine to directly access a virtual address of a thread executing on one of the plurality of processing cores. For example, an acceleration compute engine may receive one or more instructions from a thread executed by a processing core. The acceleration compute engine may retrieve, based on an address space identifier associated with the one or more instructions, a physical address associated with the one or more instructions from the translation lookaside buffer to execute the one or more instructions using the physical address.