发明授权
- 专利标题: Heterocyclic compound
- 专利标题(中): 杂环化合物
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申请号: US14235992申请日: 2012-07-27
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公开(公告)号: US09156837B2公开(公告)日: 2015-10-13
- 发明人: Satoshi Yamamoto , Junya Shirai , Atsuko Ochida , Yoshiyuki Fukase , Yoshihide Tomata , Ayumu Sato , Shotaro Miura , Kazuko Yonemori , Ryokichi Koyama
- 申请人: Satoshi Yamamoto , Junya Shirai , Atsuko Ochida , Yoshiyuki Fukase , Yoshihide Tomata , Ayumu Sato , Shotaro Miura , Kazuko Yonemori , Ryokichi Koyama
- 申请人地址: JP Osaka
- 专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人地址: JP Osaka
- 代理机构: Hamre, Schumann, Mueller & Larson, P.C.
- 优先权: JP2011-167693 20110729
- 国际申请: PCT/JP2012/069138 WO 20120727
- 国际公布: WO2013/018695 WO 20130207
- 主分类号: C07D277/30
- IPC分类号: C07D277/30 ; C07D277/56 ; C07D211/90 ; C07D417/12 ; C07D471/04 ; C07D401/12 ; C07D277/24 ; C07D401/04 ; C07D417/04 ; C07D417/14 ; C07D491/107
摘要:
A heterocyclic compound having an RORγt inhibitory activity, which is a compound of formula (I) or a salt thereof is provided. The compound has ring A, which is an optionally substituted cyclic group and is bound to a pyrazole ring though Q. Q is a bond, optionally substituted C1-10 alkylene, optionally substituted C2-10 alkenylene, or optionally substituted C2-10 alkynylene. R1 is a substituent. Ring B is a thiazole ring, an isothiazole ring or a dihydrothiazole ring, each of which is optionally further substituted by a substituent in addition to R2. R2 is an optionally substituted cyclyl-carbonyl-C1-6 alkyl group, an optionally substituted aminocarbonyl-C1-6 alkyl group, an optionally substituted cyclyl-C1-6 alkyl group, an optionally substituted cyclyl-C1-6 alkylamino-carbonyl group, an optionally substituted aminocarbonyl-C2-6 alkenyl group, an optionally substituted C1-6 alkylcarbonylamino-C1-6 alkyl group, an optionally substituted cyclyl-aminocarbonyl group, an optionally substituted cyclyl-carbonyl group or an optionally substituted non-aromatic heterocyclic group.
公开/授权文献
- US20140163001A1 HETEROCYCLIC COMPOUND 公开/授权日:2014-06-12