发明授权
US09163067B2 HIV-1 integrase derived stimulatory peptides interfering with integrase—Rev protein binding
有权
HIV-1整合酶衍生的刺激肽干扰整合酶-Rev蛋白结合
- 专利标题： HIV-1 integrase derived stimulatory peptides interfering with integrase—Rev protein binding
- 专利标题（中）： HIV-1整合酶衍生的刺激肽干扰整合酶-Rev蛋白结合
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申请号： US13122548申请日： 2009-10-01
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公开(公告)号： US09163067B2公开(公告)日： 2015-10-20
- 发明人: Aviad Levin , Zvi Hayouka , Assaf Friedler , Abraham Loyter
- 申请人： Aviad Levin , Zvi Hayouka , Assaf Friedler , Abraham Loyter
- 申请人地址： IL Jerusalem
- 专利权人： Yissum Research Development Company of The Hebrew University of Jerusalem Ltd
- 当前专利权人： Yissum Research Development Company of The Hebrew University of Jerusalem Ltd
- 当前专利权人地址： IL Jerusalem
- 代理机构： Booth Udall Fuller, PLC
- 代理商 Rodney J. Fuller
- 国际申请： PCT/IL2009/000947 WO 20091001
- 国际公布： WO2010/041241 WO 20100415
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A01N37/18 ; A61P31/18 ; A61K38/10 ; A61K38/16 ; C07K14/005
摘要：
Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
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