A manufacturing method and repair structure of a display panel are provided. A repair method for a signal wire of the display panel comprises the steps of: connecting a repair wire and a welding pad before a PSVA process, and connecting the repair wire to a short-circuit bus bar of a signal wire of the same category through the welding pad; and welding a weld point between a breakpoint and the connection point of the repair wire and the short-circuit bus bar on a broken wire, hence a signal applied to the display panel by the short-circuit bus bar is transmitted to the breakpoint through the repair wire in the PSVA process. Since the repair wire is connected with the short-circuit bus bar and directly powered up through the short-circuit bus bar in the PSVA process, the wire can not be broken when the signal is transmitted via the short-circuit bus bar, the permanent memory of the broken wire defect of the display panel in the form of a liquid crystal pre-tilt angle on the display panel during the PSVA process can be avoided, and the process yield of the display panel can be increased.