Invention Grant
US09168498B2 Method and device for producing very fine particles and coating such particles
有权
用于生产非常细小颗粒并涂覆这种颗粒的方法和装置
- Patent Title: Method and device for producing very fine particles and coating such particles
- Patent Title (中): 用于生产非常细小颗粒并涂覆这种颗粒的方法和装置
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Application No.: US12092308Application Date: 2006-10-13
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Publication No.: US09168498B2Publication Date: 2015-10-27
- Inventor: Rainer Helmut Müller , Jan Möschwitzer
- Applicant: Rainer Helmut Müller , Jan Möschwitzer
- Applicant Address: DE Wiesbaden
- Assignee: ABBVIE DEUTSCHLAND GMBH & CO KG
- Current Assignee: ABBVIE DEUTSCHLAND GMBH & CO KG
- Current Assignee Address: DE Wiesbaden
- Agency: Manelli Selter PLLC
- Agent Jeffrey S. Melcher
- Priority: DE102005053862 20051104
- International Application: PCT/EP2006/009930 WO 20061013
- International Announcement: WO2007/051520 WO 20070510
- Main IPC: B01J13/02
- IPC: B01J13/02 ; B01J2/00 ; B01F5/02 ; B01F5/04 ; B01F5/06 ; B01F11/02 ; B01F15/02 ; B01J2/02 ; B01J2/18 ; B01F7/00

Abstract:
Disclosed are methods and devices for producing very fine particles which are then coated with protective polymers in another step of the process. The particles are produced using a method in which a liquid flow comprising a particle-free liquid 1 that contains the active substance in a dissolved form is combined with a second liquid flow comprising a liquid 2 in a high-energy zone or no sooner than two seconds before reaching the high-energy zone. Said two liquids can be mixed with each other while the active substance dissolved in liquid 1 is insoluble or more difficult to dissolve in liquid 2 than in liquid 1 and settles in the form of particles in the high-energy zone or within a maximum of 2 seconds before reaching the high-energy zone when the two liquids are mixed. The obtained particles are introduced into an aqueous outer phase which contains the coating materials in a dissolved form and are then subjected to a drying step such that said materials settle on the particles as a closed coating. The coated particles are protected from damaging influences and are provided with modified release kinetics compared to uncoated particles.
Public/Granted literature
- US20090297565A1 METHOD AND DEVICE FOR PRODUCING VERY FINE PARTICLES AND COATING SUCH PARTICLES Public/Granted day:2009-12-03
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