公开(公告)号：US09168498B2

公开(公告)日：2015-10-27

申请号：US12092308

申请日：2006-10-13

Applicant: Rainer Helmut Müller ,  Jan Möschwitzer

Inventor： Rainer Helmut Müller ,  Jan Möschwitzer

IPC: B01J13/02 ,  B01J2/00 ,  B01F5/02 ,  B01F5/04 ,  B01F5/06 ,  B01F11/02 ,  B01F15/02 ,  B01J2/02 ,  B01J2/18 ,  B01F7/00

CPC classification number: B01J2/003 ,  B01F5/0256 ,  B01F5/0451 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0652 ,  B01F5/0685 ,  B01F7/00775 ,  B01F11/0258 ,  B01F15/0203 ,  B01J2/02 ,  B01J2/18

Abstract: Disclosed are methods and devices for producing very fine particles which are then coated with protective polymers in another step of the process. The particles are produced using a method in which a liquid flow comprising a particle-free liquid 1 that contains the active substance in a dissolved form is combined with a second liquid flow comprising a liquid 2 in a high-energy zone or no sooner than two seconds before reaching the high-energy zone. Said two liquids can be mixed with each other while the active substance dissolved in liquid 1 is insoluble or more difficult to dissolve in liquid 2 than in liquid 1 and settles in the form of particles in the high-energy zone or within a maximum of 2 seconds before reaching the high-energy zone when the two liquids are mixed. The obtained particles are introduced into an aqueous outer phase which contains the coating materials in a dissolved form and are then subjected to a drying step such that said materials settle on the particles as a closed coating. The coated particles are protected from damaging influences and are provided with modified release kinetics compared to uncoated particles.

Abstract translation: 公开了用于生产非常细的颗粒的方法和装置，然后在该方法的另一步骤中用保护性聚合物涂覆。 使用这样的方法制备颗粒，其中将包含溶解形式的活性物质的无颗粒液体1的液体流与包含高能区域中的液体2或不超过两个的第二液流组合 秒到达高能区。 所述两种液体可以彼此混合，而溶解在液体1中的活性物质不溶于或更难溶解在液体2中而不是液体1中，并且以高能区域中的颗粒形式或最大值为2 当两种液体混合时达到高能区之前秒钟。 将所得颗粒引入包含溶解形式的涂层材料的水性外相中，然后进行干燥步骤，使得所述材料作为封闭涂层沉积在颗粒上。 保护涂覆的颗粒免受损伤影响，并且与未涂覆的颗粒相比具有改性释放动力学。

公开(公告)号：US20090297565A1

公开(公告)日：2009-12-03

申请号：US12092308

申请日：2006-10-13

Applicant: Rainer Helmut Müller ,  Jan Möschwitzer

Inventor： Rainer Helmut Müller ,  Jan Möschwitzer

IPC: A61K9/14 ,  A61K9/00 ,  B05C19/02

CPC classification number: B01J2/003 ,  B01F5/0256 ,  B01F5/0451 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0652 ,  B01F5/0685 ,  B01F7/00775 ,  B01F11/0258 ,  B01F15/0203 ,  B01J2/02 ,  B01J2/18

Abstract: Disclosed are methods and devices for producing very fine particles which are then coated with protective polymers in another step of the process. The particles are produced using a method in which a liquid flow comprising a particle-free liquid 1 that contains the active substance in a dissolved form is combined with a second liquid flow comprising a liquid 2 in a high-energy zone or no sooner than two seconds before reaching the high-energy zone. Said two liquids can be mixed with each other while the active substance dissolved in liquid 1 is insoluble or more difficult to dissolve in liquid 2 than in liquid 1 and settles in the form of particles in the high-energy zone or within a maximum of 2 seconds before reaching the high-energy zone when the two liquids are mixed. The obtained particles are introduced into an aqueous outer phase which contains the coating materials in a dissolved form and are then subjected to a drying step such that said materials settle on the particles as a closed coating. The coated particles are protected from damaging influences and are provided with modified release kinetics compared to uncoated particles.

Abstract translation: 公开了用于生产非常细的颗粒的方法和装置，然后在该方法的另一步骤中用保护性聚合物涂覆。 使用这样的方法制备颗粒，其中将包含溶解形式的活性物质的无颗粒液体1的液体流与包含高能区域中的液体2或不超过两个的第二液流组合 秒到达高能区。 所述两种液体可以彼此混合，而溶解在液体1中的活性物质不溶于或更难溶解在液体2中而不是液体1中，并且以高能区域中的颗粒形式或最大值为2 当两种液体混合时达到高能区之前秒钟。 将所得颗粒引入包含溶解形式的涂层材料的水性外相中，然后进行干燥步骤，使得所述材料作为封闭涂层沉积在颗粒上。 保护涂覆的颗粒免受损伤影响，并且与未涂覆的颗粒相比具有改性释放动力学。

公开(公告)号：US09248101B2

公开(公告)日：2016-02-02

申请号：US11911352

申请日：2006-04-12

Applicant: Jan Möschwitzer ,  Andreas Lemke

Inventor： Jan Möschwitzer ,  Andreas Lemke

IPC: C09B69/00 ,  A61K8/04 ,  A61K9/50 ,  C09D5/00 ,  A61K9/10 ,  A61K9/16 ,  B82Y5/00

CPC classification number: A61K9/1694 ,  B82Y5/00

Abstract: The invention describes a multistage process, for producing particles with an average particle size from 50 nm to 1000 nm in a very effective and gentle manner, wherein the solid substance (active substance) is dissolved in a solvent, this liquid containing the solid substance (active substance) in dissolved form is then frozen very rapidly, the solvent/solvents used are optionally removed from the frozen matrix obtained in a (freeze-)drying process (lyophilization) or the frozen matrix is further processed directly, the solid matrix (frozen or lyophilized) is dispersed in an external phase, a liquid medium, which can be water, a mixture of water with water-miscible liquids or a non-aqueous liquid, and the resulting dispersion is then immediately exposed to high shear and/or cavitation forces, and the forces applied result in stabilization or comminution of the resulting particles in the nanometer range. The method described is particularly suitable for the processing of thermolabile and sensitive substances, since it can be performed in a manner very gentle to the product, and the wear on the devices used can be markedly decreased by reduction of the necessary cycle number or by reduction of the power density to be applied. The nanoparticles obtained can be used in various fields, e.g. in the pharmaceutical field, in the cosmetic industry, the foodstuffs industry, the textile industry and other industrial fields.

Abstract translation: 本发明描述了一种以非常有效和温和的方式生产平均粒度为50nm至1000nm的颗粒的多级方法，其中将固体物质（活性物质）溶解在溶剂中，该液体含有固体物质（ 溶解形式的活性物质）非常迅速地冷冻，所用的溶剂/溶剂任选地从（冷冻 - 干燥）干燥方法（冷冻干燥）中获得的冷冻基质中除去，或者直接进一步处理冷冻基质，固体基质 或冻干的）分散在外部相中，可以是水，水与水混溶性液体或非水性液体的混合物的液体介质，然后将得到的分散体立即暴露于高剪切和/或空化 力和施加的力导致所得颗粒在纳米范围内的稳定或粉碎。 所述方法特别适用于热不稳定和敏感物质的加工，因为它可以以对产品的温和方式进行，并且可以通过减少所需的循环次数或减少所得到的装置上的磨损而显着降低 的功率密度。 所获得的纳米颗粒可用于各种领域，例如， 在制药领域，化妆品行业，食品工业，纺织工业等工业领域。