发明授权
US09169296B2 Expression and assembly of human group C rotavirus-like particles and uses thereof
有权
人类C型轮状病毒颗粒的表达和组装及其用途
- 专利标题： Expression and assembly of human group C rotavirus-like particles and uses thereof
- 专利标题（中）： 人类C型轮状病毒颗粒的表达和组装及其用途
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申请号： US12995024申请日： 2009-05-29
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公开(公告)号： US09169296B2公开(公告)日： 2015-10-27
- 发明人: Baoming Jiang
- 申请人： Baoming Jiang
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.
- 国际申请： PCT/US2009/045688 WO 20090529
- 国际公布： WO2009/148964 WO 20091210
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C12N7/00 ; C12N7/02 ; C07K14/005 ; A61K39/00
摘要：
Group C rotaviruses are a cause of acute gastroenteritis in children and adults that is distinct from group A RV. However, human group C rotaviruses cannot be grown in culture, resulting in a lack of tools for detection and treatment of GrpC RV disease. Consequently, the burden of GpC RV disease has not been clearly established. Isolated recombinant human rotavirus group C virus-like particles are provided according to embodiments of the present invention along with methods of their production and use in, inter alia, detection of Grp C RV infection, diagnostic assays and immunogenic compositions.
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