Invention Grant
- Patent Title: Use of apoptotic cells ex vivo to generate regulatory T cells
- Patent Title (中): 使用凋亡细胞离体产生调节性T细胞
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Application No.: US11579319Application Date: 2006-11-02
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Publication No.: US09169461B2Publication Date: 2015-10-27
- Inventor: David Peritt , Kim Campbell , Amy Krutsick
- Applicant: David Peritt , Kim Campbell , Amy Krutsick
- Applicant Address: US PA Exton
- Assignee: Therakos, Inc.
- Current Assignee: Therakos, Inc.
- Current Assignee Address: US PA Exton
- Agency: Cooley LLP
- Agent Brian P. Hopkins
- International Application: PCT/US2006/042581 WO 20061102
- International Announcement: WO2007/055992 WO 20070518
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; A61K31/366 ; A61K31/59 ; A61K35/17

Abstract:
Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell (“APC”), has a high capacity to do so. The recognition of apoptotic cells (“ACs”) occurs via a series of evolutionarily-conserved, AC associated molecular-pattern receptors (“ACAMPRs”) on APCs that recognize and bind corresponding apoptotic-cell-associated molecular patterns (“ACAMPs”). These receptors recognize ligands such as phosphotidyl serine and oxidized lipids found on apoptotic cells. Savill et al. (2002); and Gregory et al. (2004).
Public/Granted literature
- US20080267934A1 Use of Apoptotic Cells Ex Vivo to Generate Regulatory T Cells Public/Granted day:2008-10-30
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