Invention Grant
US09174964B2 AMPK-activating piperidinyloxy-substituted 2,3-dihydro-1H-indene-1-amine compounds and pharmaceutical compositions including the same
有权
AMPK活化的哌啶氧基取代的2,3-二氢-1H-茚-1-胺化合物和包含它们的药物组合物
- Patent Title: AMPK-activating piperidinyloxy-substituted 2,3-dihydro-1H-indene-1-amine compounds and pharmaceutical compositions including the same
- Patent Title (中): AMPK活化的哌啶氧基取代的2,3-二氢-1H-茚-1-胺化合物和包含它们的药物组合物
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Application No.: US14053325Application Date: 2013-10-14
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Publication No.: US09174964B2Publication Date: 2015-11-03
- Inventor: Hui Hong , Xiang Xu , Jiaxin Yu , Rajinder Singh , Ihab S. Darwish , Sambaiah Thota
- Applicant: Rigel Pharmaceuticals, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Rigel Pharmaceuticals, Inc.
- Current Assignee: Rigel Pharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Agent Travis Young
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D401/12 ; C07D401/14 ; C07D211/46 ; C07D211/58 ; C07D405/14 ; C07D409/14 ; C07D413/14
Abstract:
Disclosed are carboxamide, sulfonamide and amine compounds including certain AMPK-activating piperidinylxoy-substituted 2,3-dihydro-1H-indene-1-amine compounds, as well as pharmaceutical compositions including them. One embodiment is a compound having the structure in which R1, R3,R4,R5,R14,R15,R17, G, Q, k, v, x and y are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
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