Invention Grant
US09174979B2 Phenanthroindolizidine compound and NFκB inhibitor containing same as active ingredient
有权
菲并吲哚哩啶化合物和含有与活性成分相同的NF&kgr B抑制剂
- Patent Title: Phenanthroindolizidine compound and NFκB inhibitor containing same as active ingredient
- Patent Title (中): 菲并吲哚哩啶化合物和含有与活性成分相同的NF&kgr B抑制剂
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Application No.: US13125698Application Date: 2009-10-23
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Publication No.: US09174979B2Publication Date: 2015-11-03
- Inventor: Takashi Ikeda , Seigo Sawada , Takashi Yaegashi , Takeshi Matsuzaki , Shusuke Hashimoto , Ryuta Yamazaki
- Applicant: Takashi Ikeda , Seigo Sawada , Takashi Yaegashi , Takeshi Matsuzaki , Shusuke Hashimoto , Ryuta Yamazaki
- Applicant Address: JP Tokyo
- Assignee: KABUSHIKI KAISHA YAKULT HONSHA
- Current Assignee: KABUSHIKI KAISHA YAKULT HONSHA
- Current Assignee Address: JP Tokyo
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2008-273610 20081023
- International Application: PCT/JP2009/005594 WO 20091023
- International Announcement: WO2010/047127 WO 20100429
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/437 ; A61P29/00 ; A61P35/00 ; C07D491/147

Abstract:
A novel compound having an excellent NFκB inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof:wherein, R1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom;R2 represents a hydroxyl group, or a lower alkyloxy group;R3 represents a hydrogen atom, a lower alkyl group, or a halogen atom;R4 represents a hydrogen atom or a lower alkyloxy group;R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6;R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5;R7 represents a hydrogen atom or a lower alkyl group; andR8 represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R1, R3, R4 and R7 are hydrogen atoms, R2 and R8 are hydroxyl groups, and R5 and R6 are methoxy groups).
Public/Granted literature
- US20110201638A1 PHENANTHROINDOLIZIDINE COMPOUND AND NFkB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT Public/Granted day:2011-08-18
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