PHENANTHROINDOLIZIDINE COMPOUND AND NFkB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT
    1.
    发明申请
    PHENANTHROINDOLIZIDINE COMPOUND AND NFkB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT 有权
    苯并噻唑类化合物和含有其作为活性成分的NFkB抑制剂

    公开(公告)号:US20110201638A1

    公开(公告)日:2011-08-18

    申请号:US13125698

    申请日:2009-10-23

    CPC分类号: C07D471/04 C07D491/147

    摘要: A novel compound having an excellent NFκB inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof:wherein, R1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom; R2 represents a hydroxyl group, or a lower alkyloxy group; R3 represents a hydrogen atom, a lower alkyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R1, R3, R4 and R7 are hydrogen atoms, R2 and R8 are hydroxyl groups, and R5 and R6 are methoxy groups).

    摘要翻译: 提供了具有优异的NF&Kgr B抑制效果的新化合物,具体公开了下式(1)表示的化合物或其盐:其中,R1表示氢原子,低级烷基,低级烷氧基, 或卤素原子; R2表示羟基或低级烷氧基; R3表示氢原子,低级烷基或卤素原子; R4表示氢原子或低级烷氧基; R5表示与R6一起形成的与R6或异丙烯二氧基一起形成的氢原子,低级烷氧基,卤素原子,羟基或亚甲二氧基; R6表示与R5一起形成的氢原子,低级烷氧基或亚甲二氧基,或与R5形成的异丙烯二氧基; R7表示氢原子或低级烷基; 并且R 8表示氢原子,羟基,氨基或低级烷基羰基氧基(R 1,R 3,R 4和R 7为氢原子的情况除外,R 2和R 8为羟基,R 5和R 6为甲氧基 )。

    PHENANTHROINDOLIZIDINE DERIVATIVE AND NFKB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT
    2.
    发明申请
    PHENANTHROINDOLIZIDINE DERIVATIVE AND NFKB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT 有权
    苯并呋喃衍生物和含有其作为活性成分的NFκB抑制剂

    公开(公告)号:US20110201637A1

    公开(公告)日:2011-08-18

    申请号:US13124554

    申请日:2009-10-23

    CPC分类号: C07D471/04

    摘要: A novel compound having an excellent NFκB inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a hydrogen atom, a lower alkyl group, or the like; R2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the like; R3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom.

    摘要翻译: 提供了具有优异NF&Kgr B抑制作用的新型化合物。 具体公开的是由下式(1)表示的化合物或其盐:其中,R1表示氢原子,低级烷基等; R2表示氢原子,低级烷基,卤素原子等; R3表示氢原子,低级烷基,羟基或卤素原子; R4表示氢原子或低级烷氧基; R5表示与R6一起形成的与R6或异丙烯二氧基一起形成的氢原子,低级烷氧基,卤素原子,羟基或亚甲二氧基; R6表示与R5一起形成的氢原子,低级烷氧基或亚甲二氧基,或与R5形成的异丙烯二氧基; R7表示氢原子或低级烷基; R8表示氢原子,羟基,氨基,低级烷基羰基氧基或卤素原子。

    Phenanthroindolizidine compound and NFκB inhibitor containing same as active ingredient
    3.
    发明授权
    Phenanthroindolizidine compound and NFκB inhibitor containing same as active ingredient 有权
    菲并吲哚哩啶化合物和含有与活性成分相同的NF&kgr B抑制剂

    公开(公告)号:US09174979B2

    公开(公告)日:2015-11-03

    申请号:US13125698

    申请日:2009-10-23

    CPC分类号: C07D471/04 C07D491/147

    摘要: A novel compound having an excellent NFκB inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof:wherein, R1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom;R2 represents a hydroxyl group, or a lower alkyloxy group;R3 represents a hydrogen atom, a lower alkyl group, or a halogen atom;R4 represents a hydrogen atom or a lower alkyloxy group;R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6;R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5;R7 represents a hydrogen atom or a lower alkyl group; andR8 represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R1, R3, R4 and R7 are hydrogen atoms, R2 and R8 are hydroxyl groups, and R5 and R6 are methoxy groups).

    摘要翻译: 提供了具有优异的NF&Kgr B抑制效果的新化合物,具体公开了下式(1)表示的化合物或其盐:其中,R1表示氢原子,低级烷基,低级烷氧基, 或卤素原子; R2表示羟基或低级烷氧基; R3表示氢原子,低级烷基或卤素原子; R4表示氢原子或低级烷氧基; R5表示与R6一起形成的与R6或异丙烯二氧基一起形成的氢原子,低级烷氧基,卤素原子,羟基或亚甲二氧基; R6表示与R5一起形成的氢原子,低级烷氧基或亚甲二氧基,或与R5形成的异丙烯二氧基; R7表示氢原子或低级烷基; 并且R 8表示氢原子,羟基,氨基或低级烷基羰基氧基(R 1,R 3,R 4和R 7为氢原子的情况除外,R 2和R 8为羟基,R 5和R 6为甲氧基 )。

    Phenanthroindolizidine derivative and NFκB inhibitor containing same as active ingredient
    4.
    发明授权
    Phenanthroindolizidine derivative and NFκB inhibitor containing same as active ingredient 有权
    菲咯啉二氮茚衍生物和含有与活性成分相同的NFkappaB抑制剂

    公开(公告)号:US08569327B2

    公开(公告)日:2013-10-29

    申请号:US13124554

    申请日:2009-10-23

    IPC分类号: A61K31/403 C07D221/18

    CPC分类号: C07D471/04

    摘要: A novel compound having an excellent NFκB inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a hydrogen atom, a lower alkyl group, or the like; R2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the like; R3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom.

    摘要翻译: 提供了具有优异NFκB抑制作用的新型化合物。 具体公开的是由下式(1)表示的化合物或其盐:其中,R1表示氢原子,低级烷基等; R2表示氢原子,低级烷基,卤素原子等; R3表示氢原子,低级烷基,羟基或卤素原子; R4表示氢原子或低级烷氧基; R5表示与R6一起形成的与R6或异丙烯二氧基一起形成的氢原子,低级烷氧基,卤素原子,羟基或亚甲二氧基; R6表示与R5一起形成的氢原子,低级烷氧基或亚甲二氧基,或与R5形成的异丙烯二氧基; R7表示氢原子或低级烷基; R8表示氢原子,羟基,氨基,低级烷基羰基氧基或卤素原子。

    Air-conditioning apparatus
    6.
    发明授权
    Air-conditioning apparatus 有权
    空调机

    公开(公告)号:US09513020B2

    公开(公告)日:2016-12-06

    申请号:US13820852

    申请日:2011-10-04

    摘要: There has been a problem of dew condensation, during a cooling operation, on a wind vane or the like provided at an air outlet because the wind speed of blown air leaking from ends in longitudinal direction of the air outlet is low, causing the entanglement of room air. Walls that form an air outlet from which air that has exchanged heat in a heat exchanger is blown are provided. End portions of each of the walls in a longitudinal direction of the air outlet have respective recesses such that a passage of the air therein is made wider than in a central portion of the wall. In the longitudinal direction of the air outlet, the recesses each have a downstream-side width that is smaller than an upstream-side width.

    摘要翻译: 在制冷运转时,由于在吹出口的长度方向上从端部泄漏的吹风的风速低,所以在设置在出风口的风向叶等上存在结露问题,导致了 室内空气。 提供形成在热交换器中交换了热量的空气吹出的空气出口的壁。 空气出口的纵向方向上的每个壁的端部具有相应的凹部,使得其中的空气的通道比壁的中心部分更宽。 在空气出口的纵向上,凹部各自具有小于上游侧宽度的下游侧宽度。

    Cross flow fan and air-conditioning apparatus including same
    7.
    发明授权
    Cross flow fan and air-conditioning apparatus including same 有权
    横流风扇和包括其的空调设备

    公开(公告)号:US09303649B2

    公开(公告)日:2016-04-05

    申请号:US13876561

    申请日:2011-10-12

    摘要: A cross flow fan including an impeller having at least two rings arranged with intervals in a fan rotation axis O direction and a plurality of blades that are arranged, between correlated rings, with intervals in a circumferential direction of the rings, in which the blade is divided into plural areas in the fan rotation axis O direction, and both ends adjacent to the rings are denoted as the blade-ring proximate sections and the center portion of the blade is denoted as the inter-blade-ring center section. The blade is formed such that the thickness of the inner peripheral blade end of the blade that is the inner peripheral end of the impeller is smaller in the inter-blade-ring center section than in the blade-ring proximate section.

    摘要翻译: 一种横流风扇,包括具有沿风扇旋转轴线O方向间隔布置的至少两个环的叶轮和在相关环之间以环的周向间隔布置的多个叶片,其中叶片为 分为风扇旋转轴O方向上的多个区域,并且与环相邻的两端被表示为叶片环近似部分,并且叶片的中心部分被表示为叶片间中心部分。 叶片形成为使叶片的内周端部的叶片的内周侧叶片的厚度在叶片间环中央部比叶片环近侧部分小。

    Cross flow fan, air blower and air conditioner
    8.
    发明授权
    Cross flow fan, air blower and air conditioner 有权
    横流风机,鼓风机和空调

    公开(公告)号:US09039347B2

    公开(公告)日:2015-05-26

    申请号:US13497287

    申请日:2010-09-07

    IPC分类号: F04D17/04 F04D29/28 F04D29/30

    摘要: Disclosed is a cross flow fan that makes uniform a distribution of wind velocity along an axial direction of the fan at an exit of an air trunk and that lessens chance of separation of an air flow on an inlet side of the fan, and there are thereby provided a cross flow fan that accomplishes a lower input and smaller noise and an air blower and an air conditioner that use the cross flow fan. A cross flow fan being rotatably placed in a horizontally-long air trunk, and including a plurality of annular rings that are substantially parallel to each other and a plurality of blades that are radially interposed between adjacent rings, each having a circular arc cross sectional shape, and a camber angle of the blade is smaller at the ring side than at a center area of the blade between the rings in a longitudinal direction.

    摘要翻译: 公开了一种横流风扇,其在空气导管的出口处沿着风扇的轴向均匀地分布风速,并且减少了风扇入口侧上的气流的分离机会,因此, 提供了实现更低输入和更小噪声的横流风扇,以及使用横流风扇的鼓风机和空调。 横流风扇可旋转地设置在水平长的空气干燥箱中,并且包括彼此基本平行的多个环形圈和径向插入相邻环之间的多个叶片,每个叶片具有圆弧形横截面形状 并且所述叶片的外倾角在长度方向上在所述环之间比所述叶片在所述叶片的中心区域处小。

    Wall-mounted air-conditioning apparatus
    10.
    发明授权
    Wall-mounted air-conditioning apparatus 有权
    壁挂式空调机

    公开(公告)号:US08910492B2

    公开(公告)日:2014-12-16

    申请号:US13382402

    申请日:2009-12-24

    摘要: An upper suction port is formed in a main-body upper part of an air-conditioning apparatus main body, a suction opening part is formed in a front grill disposed on a main-body front face of the air-conditioning apparatus, a suction opening whose opening is directed upward is formed by consecutively providing an air guide wall inclined downward inside the main body on the upper edge of the suction opening, and the suction opening is located between a part, in the main-body height direction, lower than a straight line passing through a rotation center of an impeller and a closest contact point between the impeller and a front-face heat exchanger and a part, in the main-body height direction, higher than a straight line parallel with the straight line and passing through the impeller and a tongue part of a stabilizer.

    摘要翻译: 在空调装置主体的主体上部形成有上吸入口,在设置在空调装置的主体前面的前格栅上形成吸入口部,吸入口 其开口朝向上方形成有连续地设置在吸入口的上边缘的主体内向下倾斜的导气壁,吸入口位于主体高度方向的一部分之间,低于 通过叶轮的旋转中心的直线和叶轮与前表面热交换器之间的最接近的接触点,并且在主体高度方向上的直线高于与直线平行的直线并通过 叶轮和稳定器的舌部分。