An endoluminal prosthesis and systems and methods for making the prosthesis are provided. In one example, a patterned graft material for a prosthesis includes a network of electrospun fibers. The network of electrospun fibers may include a plurality of continuous electrospun fibers. The fibers may be collected on a collector plate using an electrospinning process to form the network of fibers. The patterned graft material also may include a plurality of openings in the network of electrospun fibers. The plurality of openings may be arranged in a pattern. The network of electrospun fibers may include a plurality of edges, each surrounding a corresponding one of the plurality of openings. Each of the plurality of edges may include at least one electrospun fiber of the network of electrospun fibers. A majority of the electrospun fibers of the plurality of edges may be continuous at the edges.