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公开(公告)号：US09175427B2
公开(公告)日：2015-11-03
申请号：US13295589
申请日：2011-11-14
Applicant: Kenneth A. Haselby , Keith R. Milner , Sara M. Sherman , Seoggwan Kim , Richard A. Swift
Inventor： Kenneth A. Haselby , Keith R. Milner , Sara M. Sherman , Seoggwan Kim , Richard A. Swift
CPC classification number: D04H1/728 , A61F2/07 , A61F2250/0001 , D01D5/0076 , Y10T428/24273
Abstract: An endoluminal prosthesis and systems and methods for making the prosthesis are provided. In one example, a patterned graft material for a prosthesis includes a network of electrospun fibers. The network of electrospun fibers may include a plurality of continuous electrospun fibers. The fibers may be collected on a collector plate using an electrospinning process to form the network of fibers. The patterned graft material also may include a plurality of openings in the network of electrospun fibers. The plurality of openings may be arranged in a pattern. The network of electrospun fibers may include a plurality of edges, each surrounding a corresponding one of the plurality of openings. Each of the plurality of edges may include at least one electrospun fiber of the network of electrospun fibers. A majority of the electrospun fibers of the plurality of edges may be continuous at the edges.
Abstract translation: 提供了一种用于制造假体的腔内假体和系统和方法。 在一个实例中，用于假体的图案化移植材料包括电纺纤维网络。 电纺纤维的网络可以包括多个连续的电纺丝纤维。 可以使用电纺丝方法将纤维收集在收集板上以形成纤维网。 图案化的移植材料还可以包括电纺纤维网络中的多个开口。 多个开口可以以图案布置。 电纺纤维的网络可以包括多个边缘，每个边缘围绕多个开口中的对应的一个开口。 多个边缘中的每一个可以包括电纺纤维网络的至少一个电纺纤维。 多个边缘中的大多数电纺丝纤维可以在边缘处是连续的。
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公开(公告)号：US09060852B2
公开(公告)日：2015-06-23
申请号：US13438549
申请日：2012-04-03
Applicant: David G. Grewe , Keith R. Milner , Blayne A. Roeder , Steven J. Charlebois
Inventor： David G. Grewe , Keith R. Milner , Blayne A. Roeder , Steven J. Charlebois
CPC classification number: A61F2/82 , A61F2/07 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/072 , A61F2002/075 , A61F2002/91566 , A61F2220/005 , A61F2240/001 , A61L31/022 , A61L31/10 , A61L2420/02
Abstract: A method of making a stent-graft is provided. The method includes mounting a stent on a mandrel so that the stent is stretched when it is on the mandrel. A graft layer is then adhered to the stent while it is mounted on the mandrel. When the stent-graft is removed from the mandrel, the stent contracts and the graft layer becomes partially wrinkled when the stent is in its expanded relaxed state.
Abstract translation: 提供一种制造支架移植物的方法。 该方法包括将支架安装在心轴上，使得支架在心轴上时被拉伸。 接枝层然后在其被安装在心轴上时粘附到支架上。 当支架移植物从心轴移除时，当支架处于其膨胀的松弛状态时，支架收缩并且移植层变得部分起皱。
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3.发明申请公开(公告)号：US20130046282A1
公开(公告)日：2013-02-21
申请号：US13695915
申请日：2011-05-03
Applicant: Therese O'Day , Frank J. Fisher , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
Inventor： Therese O'Day , Frank J. Fisher , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
CPC classification number: A61M25/007
Abstract: A method of treating an intravascular site in a patient includes spraying jets of treatment fluid out of spray orifices formed in an elongate catheter body, and changing an impingement pattern of the treatment fluid on material within the intravascular site in response to a torque induced by a back pressure of the jets. A thrombolysis catheter includes an elongate catheter body having a plurality of spray orifices formed in a body wall, and communicating with a fluid lumen longitudinally extending in the elongate catheter body. The plurality of spray orifices define a torque inducing spray jet pattern, whereby a back pressure of spray jets exiting the spray orifices induces a torque on the elongate catheter body.
Abstract translation: 一种治疗患者血管内部位的方法包括从形成于细长导管体内的喷孔喷射治疗液的喷射，并且响应于由所述血管内位置引起的扭矩，改变治疗流体在血管内部位内的材料的冲击模式 喷气机的背压。 溶栓导管包括细长导管主体，其具有形成在体壁中的多个喷孔，并且与在细长导管主体中纵向延伸的流体腔连通。 多个喷射孔限定了转矩诱导喷射喷射图案，由此离开喷嘴的喷射射流的背压在细长导管主体上引起扭矩。
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公开(公告)号：US20130122248A1
公开(公告)日：2013-05-16
申请号：US13295589
申请日：2011-11-14
Applicant: Kenneth A. Haselby , Keith R. Milner , Sara M. Sherman , Seoggwan Kim , Richard A. Swift
Inventor： Kenneth A. Haselby , Keith R. Milner , Sara M. Sherman , Seoggwan Kim , Richard A. Swift
CPC classification number: D04H1/728 , A61F2/07 , A61F2250/0001 , D01D5/0076 , Y10T428/24273
Abstract: An endoluminal prosthesis and systems and methods for making the prosthesis are provided. In one example, a patterned graft material for a prosthesis includes a network of electrospun fibers. The network of electrospun fibers may include a plurality of continuous electrospun fibers. The fibers may be collected on a collector plate using an electrospinning process to form the network of fibers. The patterned graft material also may include a plurality of openings in the network of electrospun fibers. The plurality of openings may be arranged in a pattern. The network of electrospun fibers may include a plurality of edges, each surrounding a corresponding one of the plurality of openings. Each of the plurality of edges may include at least one electrospun fiber of the network of electrospun fibers. A majority of the electrospun fibers of the plurality of edges may be continuous at the edges.
Abstract translation: 提供了一种用于制造假体的腔内假体和系统和方法。 在一个实例中，用于假体的图案化移植材料包括电纺纤维网络。 电纺纤维的网络可以包括多个连续的电纺丝纤维。 可以使用电纺丝方法将纤维收集在收集板上以形成纤维网。 图案化的移植材料还可以包括电纺纤维网络中的多个开口。 多个开口可以以图案布置。 电纺纤维的网络可以包括多个边缘，每个边缘围绕多个开口中的对应的一个开口。 多个边缘中的每一个可以包括电纺纤维网络的至少一个电纺纤维。 多个边缘中的大多数电纺丝纤维可以在边缘处是连续的。
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公开(公告)号：US20120259170A1
公开(公告)日：2012-10-11
申请号：US13438549
申请日：2012-04-03
Applicant: David G. Grewe , Keith R. Milner , Blayne A. Roeder , Steven J. Charlebois
Inventor： David G. Grewe , Keith R. Milner , Blayne A. Roeder , Steven J. Charlebois
IPC: A61F2/06
CPC classification number: A61F2/82 , A61F2/07 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/072 , A61F2002/075 , A61F2002/91566 , A61F2220/005 , A61F2240/001 , A61L31/022 , A61L31/10 , A61L2420/02
Abstract: A method of making a stent-graft is provided. The method includes mounting a stent on a mandrel so that the stent is stretched when it is on the mandrel. A graft layer is then adhered to the stent while it is mounted on the mandrel. When the stent-graft is removed from the mandrel, the stent contracts and the graft layer becomes partially wrinkled when the stent is in its expanded relaxed state.
Abstract translation: 提供一种制造支架移植物的方法。 该方法包括将支架安装在心轴上，使得支架在心轴上时被拉伸。 接枝层然后在其被安装在心轴上时粘附到支架上。 当支架移植物从心轴移除时，当支架处于其膨胀的松弛状态时，支架收缩并且移植层变得部分起皱。
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Patent Agency Ranking
公开(公告)号：US09205224B2
公开(公告)日：2015-12-08
申请号：US12756400
申请日：2010-04-08
Applicant: Therese O'Day , Frank J. Fischer, Jr. , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
Inventor： Therese O'Day , Frank J. Fischer, Jr. , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
CPC classification number: A61M25/003 , A61M25/002 , A61M25/007 , A61M25/0108 , A61M2025/004 , A61M2025/0073 , A61M2025/0079 , A61M2025/0183 , A61M2025/09175
Abstract: An infusion mechanism for treating an intraluminal site in a patient includes an infusion catheter having an elongate body with a proximal body end defining at least one fluid supply orifice, and a distal body end. The elongate body defines a high head loss lumen in fluid communication with a first set of side ports defining a proximal infusion zone. The elongate body further defines a low head loss lumen in fluid communication with a second set of side ports defining a distal infusion zone.
Abstract translation: 用于治疗患者的管腔内部位的输注机构包括具有细长体的输注导管，其具有限定至少一个流体供应孔的近端体端和远端本体端。 细长体限定了与限定近端输注区的第一组侧端口流体连通的高头损失腔。 细长体进一步限定与限定远端输注区的第二组侧端口流体连通的低头损失腔。
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公开(公告)号：US20110251588A1
公开(公告)日：2011-10-13
申请号：US12756400
申请日：2010-04-08
Applicant: Therese O'Day , Frank J. Fischer, JR. , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
Inventor： Therese O'Day , Frank J. Fischer, JR. , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
CPC classification number: A61M25/003 , A61M25/002 , A61M25/007 , A61M25/0108 , A61M2025/004 , A61M2025/0073 , A61M2025/0079 , A61M2025/0183 , A61M2025/09175
Abstract: An infusion mechanism for treating an intraluminal site in a patient includes an infusion catheter having an elongate body with a proximal body end defining at least one fluid supply orifice, and a distal body end. The elongate body defines a high head loss lumen in fluid communication with a first set of side ports defining a proximal infusion zone. The elongate body further defines a low head loss lumen in fluid communication with a second set of side ports defining a distal infusion zone.
Abstract translation: 用于治疗患者的管腔内部位的输注机构包括具有细长体的输注导管，其具有限定至少一个流体供应孔的近端体端和远端本体端。 细长体限定了与限定近端输注区的第一组侧端口流体连通的高头损失腔。 细长体进一步限定与限定远端输注区的第二组侧端口流体连通的低头损失腔。
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8.发明授权公开(公告)号：US09314589B2
公开(公告)日：2016-04-19
申请号：US13695915
申请日：2011-05-03
Applicant: Therese O'Day , Frank J. Fisher , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
Inventor： Therese O'Day , Frank J. Fisher , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
IPC: A61M25/00
CPC classification number: A61M25/007
Abstract: A method of treating an intravascular site in a patient includes spraying jets of treatment fluid out of spray orifices formed in an elongate catheter body, and changing an impingement pattern of the treatment fluid on material within the intravascular site in response to a torque induced by a back pressure of the jets. A thrombolysis catheter includes an elongate catheter body having a plurality of spray orifices formed in a body wall, and communicating with a fluid lumen longitudinally extending in the elongate catheter body. The plurality of spray orifices define a torque inducing spray jet pattern, whereby a back pressure of spray jets exiting the spray orifices induces a torque on the elongate catheter body.
Abstract translation: 一种治疗患者血管内部位的方法包括从形成于细长导管体内的喷孔喷射治疗液的喷射，并且响应于由所述血管内位置引起的扭矩，改变治疗流体在血管内部位内的材料的冲击模式 喷气机的背压。 溶栓导管包括细长导管主体，其具有形成在体壁中的多个喷孔，并且与在细长导管主体中纵向延伸的流体腔连通。 多个喷射孔限定了转矩诱导喷射喷射图案，由此离开喷嘴的喷射射流的背压在细长导管主体上引起扭矩。
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9.发明授权Spray system and method of making phase separated polymer membrane structures 有权制备相分离聚合物膜结构的喷雾系统和方法公开(公告)号：US08535590B2
公开(公告)日：2013-09-17
申请号：US13005090
申请日：2011-01-12
Applicant: Keith R. Milner , Matthew S. Huser
Inventor： Keith R. Milner , Matthew S. Huser
CPC classification number: B29C41/003 , B05B13/0214 , B05B13/0442 , B29C41/085 , B29C41/365 , B29C41/52 , B29L2031/7532 , B29L2031/755
Abstract: A spray system and method of using such spray system to fabricate a polymer membrane structure for use as a vascular graft or tissue engineered scaffold is provided. Generally, this spray system includes the use of at least two spray apparatus to apply different polymer and solvent mixtures to the outer surface of a mandrel to form a blended layer. Upon curing of the blended layer, phase separation occurs leading to the formation of a polymer membrane structure having variable properties along at least a portion of its longitudinal axis.
Abstract translation: 提供了一种使用这种喷雾系统制造用作血管移植物或组织工程支架的聚合物膜结构的喷雾系统和方法。 通常，该喷雾系统包括使用至少两个喷雾装置以将不同的聚合物和溶剂混合物施加到心轴的外表面以形成混合层。 在混合层固化后，发生相分离，导致在其纵轴的至少一部分上形成具有可变性质的聚合物膜结构。
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公开(公告)号：US20130138202A1
公开(公告)日：2013-05-30
申请号：US13761391
申请日：2013-02-07
Applicant: Ram H. Paul , Richard A. Swift , Oliver Bach , Ralf Steiner , Angela R. Barnett , Keith R. Milner
Inventor： Ram H. Paul , Richard A. Swift , Oliver Bach , Ralf Steiner , Angela R. Barnett , Keith R. Milner
IPC: A61F2/82
CPC classification number: A61F2/82 , A61F2/07 , A61F2/848 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2002/91558 , A61F2002/91575 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2250/0023 , A61F2250/0036 , A61F2250/0037
Abstract: A perfusion device and a delivery system for repair of a damaged portion of a body vessel. Perfusion device can include a tubular body that is self-expandable, having a proximal portion, a distal portion, and an intermediate portion. One or more series of barbs can be disposed circumferentially along the intermediate portion. Barbs are capable of penetrating into the tunica intima and tunica media of said vessel wall upon insertion of said device into said body vessel, and not into said tunica adventitia. A graft can be associated with the tubular body. Graft has a proximal end and a distal end, and preferably extends entirely along a luminal wall of the tubular body. Graft may also extend along an exterior surface of the tubular body at the proximal and distal portions. A remodelable covering can be applied along the intermediate portion. Delivery devices for the perfusion implant and methods of delivering the perfusion implant are also provided.
Abstract translation: 灌注装置和用于修复身体血管损伤部分的输送系统。 灌注装置可以包括可自膨胀的管状体，其具有近端部分，远端部分和中间部分。 一个或多个串联的倒钩可以沿着中间部分周向设置。 倒钩在将所述装置插入所述身体容器中时能够渗入所述血管壁的中膜和中膜，并且不会进入所述外膜。 移植物可以与管状体相关联。 移植物具有近端和远端，优选地沿管状体的腔壁完全延伸。 移植物也可以在近端部分和远端部分沿管状体的外表面延伸。 可以沿着中间部分施加可重塑的覆盖物。 还提供用于灌注植入物的递送装置和递送灌注植入物的方法。
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