A method of performing a handover in a wireless communication system employing a macro base station and a femto base station is provided. The method comprising: monitoring an uplink signal transmitted from a user equipment to the macro base station; transmitting a handover initiation message to the macro base station on the basis of a result of comparing the uplink signal's strength obtained by the monitoring with a reference value; and performing a handover of the user equipment from the macro base station to the femto base station. According to the present invention, there is provided a method of initiating a handover by a femto base station by fining user equipments located in a cell coverage of the femto base station. In addition, a signaling overhead is reduced by utilizing previously existing information such as uplink transmit power.