Techniques for mapping applications to radios in a wireless communication device are described. In one design, a controller residing below an operating system may receive inputs from applications residing above the operating system. The controller may determine radios selected based on the application inputs and further to mitigate interference between these radios. The controller may determine mapping of the applications to the radios based on the application inputs and may provide, to the applications, information indicative of the radios to which the applications are mapped. The applications may obtain connectivity via their selected radios. The controller may interface with entities in both upper layers and lower layers to facilitate radio selection and application-to-radio mapping. The controller may control the operation of a connection manager and/or a coexistence manager, manage databases for these managers, provide CPU and memory resources for these managers, manage a data bus used for communication, etc.