Invention Grant
US09186356B2 Methods for treating frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U)
有权
用泛素化包涵体（FTLD-U）治疗额颞叶变性的方法
- Patent Title: Methods for treating frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U)
- Patent Title (中): 用泛素化包涵体（FTLD-U）治疗额颞叶变性的方法
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Application No.: US13343686Application Date: 2012-01-04
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Publication No.: US09186356B2Publication Date: 2015-11-17
- Inventor: Che-Kun James Shen , Kuen-Jer Tsai
- Applicant: Che-Kun James Shen , Kuen-Jer Tsai
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Agency: Intellectual Property Connections, Inc.
- Agent Hsiu-Ming Saunders
- Main IPC: A61K31/4436
- IPC: A61K31/4436 ; A61K31/132 ; A61K31/138 ; A61K31/513 ; A61K31/55 ; A61K31/7016 ; A61K31/4433
Abstract:
Methods for rescuing learning, memory and/or motor function deficits associated with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) are disclosed. The method comprises: a) administering to an animal having FTLD-U a therapeutically effective amount of an autophagy inducer; b) causing a decrease in the amount of ubiquitinated TDP-43 aggregation forms in the brain of the animal; and c) causing an improvement of the learning, memory capacities and/or motor function of the animal.
Public/Granted literature
- US20120178775A1 METHODS FOR TREATING FRONTOTEMPORAL LOBAR DEGENERATION WITH UBIQUITINATED INCLUSIONS (FTLD-U) Public/Granted day:2012-07-12
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