发明授权
- 专利标题： Bicyclic pyridazine compounds as Pim inhibitors
- 专利标题（中）： 双环哒嗪化合物作为Pim抑制剂
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申请号： US14114481申请日： 2012-04-19
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公开(公告)号： US09187486B2公开(公告)日： 2015-11-17
- 发明人: Derin C. D'amico , Bradley J. Herberich , Claire L. M. Jackson , Liping H. Pettus , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
- 申请人： Derin C. D'amico , Bradley J. Herberich , Claire L. M. Jackson , Liping H. Pettus , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： US CA Thousand Oaks
- 代理商 Bernard P. Friedrichsen
- 国际申请： PCT/US2012/034272 WO 20120419
- 国际公布： WO2012/148775 WO 20121101
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
摘要：
The invention relates to bicyclic compounds of formulas I and I′, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
公开/授权文献
- US20140221344A1 Bicyclic Pyridazine Compounds as PIM Inhibitors 公开/授权日：2014-08-07
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