发明授权
US09187494B2 Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
有权
芳基取代的三环磺酰胺作为甲硫氨酰氨基肽酶2调节剂
- 专利标题： Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
- 专利标题（中）： 芳基取代的三环磺酰胺作为甲硫氨酰氨基肽酶2调节剂
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申请号： US14116026申请日： 2012-05-07
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公开(公告)号： US09187494B2公开(公告)日： 2015-11-17
- 发明人: Susan Mary Cramp , Hazel Joan Dyke , Thomas David Pallin , Robert Zahler
- 申请人： Susan Mary Cramp , Hazel Joan Dyke , Thomas David Pallin , Robert Zahler
- 申请人地址： US MA Boston
- 专利权人： Zafgen, Inc.
- 当前专利权人： Zafgen, Inc.
- 当前专利权人地址： US MA Boston
- 代理机构： Goodwin Procter LLP
- 国际申请： PCT/US2012/036792 WO 20120507
- 国际公布： WO2012/154678 WO 20121115
- 主分类号： A61K31/10
- IPC分类号： A61K31/10 ; C07C317/14 ; C07D498/04 ; C07D471/04 ; C07D487/04
摘要：
The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2. For example, the invention relates in part to tricyclic sulfonamide compounds represented by Formula I: or pharmaceutically acceptable salts or stereoisomers thereof, wherein A, B, D, RA1, RA2, Y, X, and n are as defined herein.
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