The present invention relates to a wireless communication system. More particularly, the present invention relates to a method and apparatus for transmitting an uplink signal in a wireless communication system, wherein the method for transmitting an uplink signal in a wireless communication system comprises: a step of receiving a control channel signal containing resource allocation information; and a step of transmitting an uplink signal in accordance with the control channel signal, wherein the resource allocation information has a combination index r to be used for indicating two sets of resource blocks, and each set of resource blocks includes one or more continuous resource blocks.