Invention Grant
- Patent Title: Bead manipulation techniques
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Application No.: US14697058Application Date: 2015-04-27
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Publication No.: US09205433B2Publication Date: 2015-12-08
- Inventor: Prasanna Thwar , Vamsee K. Pamula , Arjun Sudarsan , Ramakrishna Sista
- Applicant: ADVANCED LIQUID LOGIC, INC.
- Applicant Address: US CA San Diego
- Assignee: Advanced Liquid Logic, Inc.
- Current Assignee: Advanced Liquid Logic, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Ward and Smith, P.A.
- Agent William A. Barrett; Ryan K. Simmons
- Main IPC: G01N15/06
- IPC: G01N15/06 ; G01N33/00 ; G01N33/48 ; B03C5/00

Abstract:
The invention provides a method of redistributing magnetically responsive beads in a droplet. The method may include conducting on a droplet operations surface one or more droplet operations using the droplet without removing the magnetically responsive beads from the region of the magnetic field. The droplet operations may in some cases be electrode-mediated. The droplet operations may redistribute and/or circulate the magnetically responsive beads within the droplet. In some cases, the droplet may include a sample droplet may include a target analyte. The redistributing of the magnetically responsive beads may cause target analyte to bind to the magnetically responsive beads. In some cases, the droplet may include unbound substances in a wash buffer. The redistributing of the magnetically responsive beads causes unbound substances to be freed from interstices of an aggregated set or subset of the magnetically responsive beads.
Public/Granted literature
- US20150238975A1 BEAD MANIPULATION TECHNIQUES Public/Granted day:2015-08-27
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