Invention Grant
US09206181B2 1-aza-bicyclo[3.3.1] non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-AChR for the treatment of psychotic and neurodegenerative disorders
有权
1-氮杂 - 双环[3.3.1]壬-4-基） - [5-（1H-吲哚-5-基） - 杂芳基] - 胺作为用于治疗精神病和神经变性疾病的n-AChR的胆碱能配体
![1-aza-bicyclo[3.3.1] non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-AChR for the treatment of psychotic and neurodegenerative disorders](/docs/US/2015-12-08/US09206181B2/abs.jpg.600x600.jpg)
- Patent Title: 1-aza-bicyclo[3.3.1] non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-AChR for the treatment of psychotic and neurodegenerative disorders
- Patent Title (中): 1-氮杂 - 双环[3.3.1]壬-4-基） - [5-（1H-吲哚-5-基） - 杂芳基] - 胺作为用于治疗精神病和神经变性疾病的n-AChR的胆碱能配体
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Application No.: US14285942Application Date: 2014-05-23
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Publication No.: US09206181B2Publication Date: 2015-12-08
- Inventor: Mathias Frederiksen , Dominik Feuerbach , Konstanze Hurth , Manuel Koller , Bernard Lucien Roy
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Shawn D. Britt
- Priority: GB0525673.0 20051216
- Main IPC: C07D471/08
- IPC: C07D471/08 ; A61K31/429
![1-aza-bicyclo[3.3.1] non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-AChR for the treatment of psychotic and neurodegenerative disorders](/abs-image/US/2015/12/08/US09206181B2/abs.jpg.150x150.jpg)
Abstract:
The present invention related to compounds of formula (I) wherein n represents 0, 1, 2, 3, 4 or 5, R represents independent from each other hydroxyl, cyano, nitro, halogen, alkyl, alkoxy alkylcarbonyl, alkoxycarbonyl, alkylamine, dialkylamine, alkylcarbonylamine, alkylcarbamate Y represents one of the following groups: (Ia) in free base or acid addition salt form, to processes for their production, to pharmaceutical compositions comprising them and their use in the manufacture of a medicament for the treatment and/or delay of progression of psychotic and neurodegenerative disorders.
Public/Granted literature
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