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    1-aza-bicyclo[3.3.1] non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-AChR for the treatment of psychotic and neurodegenerative disorders
    3.
    发明授权
    1-aza-bicyclo[3.3.1] non-4-yl)-[5-(1H-indol-5-yl)-heteroaryl]-amines as cholinergic ligands of the n-AChR for the treatment of psychotic and neurodegenerative disorders 有权
    1-氮杂 - 双环[3.3.1]壬-4-基） - [5-（1H-吲哚-5-基） - 杂芳基] - 胺作为用于治疗精神病和神经变性疾病的n-AChR的胆碱能配体

    公开(公告)号：US09206181B2

    公开(公告)日：2015-12-08

    申请号：US14285942

    申请日：2014-05-23

    Applicant: NOVARTIS AG

    Inventor： Mathias Frederiksen ,  Dominik Feuerbach ,  Konstanze Hurth ,  Manuel Koller ,  Bernard Lucien Roy

    IPC: C07D471/08 ,  A61K31/429

    CPC classification number: C07D471/08 ,  A61K31/429

    Abstract: The present invention related to compounds of formula (I) wherein n represents 0, 1, 2, 3, 4 or 5, R represents independent from each other hydroxyl, cyano, nitro, halogen, alkyl, alkoxy alkylcarbonyl, alkoxycarbonyl, alkylamine, dialkylamine, alkylcarbonylamine, alkylcarbamate Y represents one of the following groups: (Ia) in free base or acid addition salt form, to processes for their production, to pharmaceutical compositions comprising them and their use in the manufacture of a medicament for the treatment and/or delay of progression of psychotic and neurodegenerative disorders.

    Abstract translation: 本发明涉及式（I）化合物，其中n表示0,1,2,3,4或5，R表示彼此独立的羟基，氰基，硝基，卤素，烷基，烷氧基烷基羰基，烷氧基羰基，烷基胺，二烷基胺 ，烷基羰基胺，烷基氨基甲酸酯Y代表以下基团之一：游离碱或酸加成盐形式的（Ia），其制备方法，包含它们的药物组合物及其在制备用于治疗和/或 延迟精神病和神经退行性疾病的进展。

    1-aza-bicyclo[3.3.1]nonanes
    10.
    发明授权
    1-aza-bicyclo[3.3.1]nonanes 有权
    1-氮杂 - 双环[3.3.1]壬烷

    公开(公告)号：US09475811B2

    公开(公告)日：2016-10-25

    申请号：US14558776

    申请日：2014-12-03

    Applicant: NOVARTIS AG

    Inventor： Dominik Feuerbach ,  Werner Müller ,  Bernard Lucien Roy ,  Thomas Troxler ,  Konstanze Hurth ,  Mathias Frederiksen

    IPC: C07D471/08

    CPC classification number: C07D471/08

    Abstract: The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I); wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them. Formula (I), wherein A represents O or N(R1); Y represents a group of formula, or wherein the left bond is attached to the A group and the right bond is attached to the R group; R represents a substituted or unsubstituted C5-C10aryl, substituted or unsubstituted hetero-C5-C10aryl, a group N(R1)(R4), or a group N(R2)(CHP3R4); R represent a hydrogen, C1-C4alkyl, or CF3; R2 represents hydrogen, C1-C4alkyl, or CF3; R3 represents hydrogen, C1-C4alkyl, or CF3; R4 represents a substituted or unsubstituted C5-C10 aryl or a substituted or unsubstituted C5-C10heteroaryl; in free base or acid addition salt form.

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