A control device of an internal combustion engine according to the present invention has units configured to inject fuel at a first predetermined ratio from first and second fuel injection valves which are provided in each of cylinders to calculate a first value indicating a degree of variation in air-fuel ratios between the cylinders based on a output of the engine, and inject fuel at a second predetermined ratio therefrom to calculate a second value in the same manner. Furthermore, the control device has a unit configured to select one mode from modes relating to abnormality in the first fuel injection valve or the second fuel injection valve on the basis of the first and second values, and calculate a value indicating the degree of the variation in the air-fuel ratios between the cylinders, thereby calculating a fuel amount of the basis of them.