A wireless device is configured with a primary cell group and a secondary cell group. When a first time alignment timer of the primary cell group expires, for each cell in the wireless device, the wireless device stops uplink transmission of HARQ feedback, uplink transport blocks, and channel state information. When a second time alignment timer of the secondary cell group expires and the first time alignment timer is running, for each activated cell in the secondary cell group, the wireless device stops transmission of uplink transport blocks, and continues transmission of HARQ feedback and channel state information.