发明授权
- 专利标题： siRNA conjugate and preparation method thereof
- 专利标题（中）： siRNA共轭体及其制备方法
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申请号： US14291540申请日： 2014-05-30
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公开(公告)号： US09211343B2公开(公告)日： 2015-12-15
- 发明人: Bo Ram Han , Han Oh Park , Mi Sik Shin , Sam Young Lee
- 申请人： Bioneer Corporation
- 申请人地址： KR Daejeon
- 专利权人： BIONEER CORPORATION
- 当前专利权人： BIONEER CORPORATION
- 当前专利权人地址： KR Daejeon
- 代理机构： Hultquist, PLLC
- 代理商 Steven J. Hultquist; Mary B. Grant
- 优先权： KR10-2009-0042297 20090514
- 主分类号： A61K47/00
- IPC分类号： A61K47/00 ; A61K9/107 ; A61K47/48 ; C07H21/02 ; C12N15/11 ; C08G65/335 ; C07F7/08 ; C12N15/113 ; B82Y5/00 ; A61K47/34
摘要：
Provided are an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalently bonding siRNA and a polymeric compound for improving the in vivo stability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the in vivo stability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relative low concentration. Therefore, the conjugate can advantageously be used as not only an siRNA treatment tool for cancers and other infectious disease, but also a novel type siRNA delivery system.
公开/授权文献
- US20140350232A1 SIRNA CONJUGATE AND PREPARATION METHOD THEREOF 公开/授权日：2014-11-27
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