发明授权
- 专利标题： Chimeric antigen receptors with an optimized hinge region
- 专利标题（中）： 具有优化铰链区的嵌合抗原受体
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申请号： US13821491申请日： 2011-09-06
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公开(公告)号： US09212229B2公开(公告)日： 2015-12-15
- 发明人: Kurt Schönfeld , Christiane Knopp , Winfried Wels
- 申请人： Kurt Schönfeld , Christiane Knopp , Winfried Wels
- 申请人地址： DE Frankfurt am Main
- 专利权人： CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS
- 当前专利权人： CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS
- 当前专利权人地址： DE Frankfurt am Main
- 代理机构： Saliwanchik, Lloyd & Eisenschenk
- 优先权： EP10009345 20100908
- 国际申请： PCT/EP2011/004490 WO 20110906
- 国际公布： WO2012/031744 WO 20120315
- 主分类号： C12N15/63
- IPC分类号： C12N15/63 ; C07K14/46 ; C07K16/32 ; C07K16/46 ; C07K14/725 ; C07K14/705
摘要：
The present invention relates to multi-functional proteins which comprise (i) a signal peptide, (ii) a target specific recognition domain, (iii) a linker region, connecting domain (ii) and domain (iv) which comprises a specific modified hinge region of the human CD8 alpha-chain, and (iv) an effector domain. The present invention furthermore relates to nucleic acids encoding the proteins, expression constructs for expressing the protein in a host cell and host cells. The proteins of the invention are chimeric antigen receptors with an optimized linker or hinge region that are suitable for generating target-specific effector cells, for use as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy.
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