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    CHIMERIC ANTIGEN RECEPTORS WITH AN OPTIMIZED HINGE REGION
    1.
    发明申请
    CHIMERIC ANTIGEN RECEPTORS WITH AN OPTIMIZED HINGE REGION 有权
    具有优化的HINGE区域的CHIMERIC抗原受体

    公开(公告)号：US20130280285A1

    公开(公告)日：2013-10-24

    申请号：US13821491

    申请日：2011-09-06

    申请人： Kurt Schönfeld ,  Christiane Knopp ,  Winfried Wels

    发明人： Kurt Schönfeld ,  Christiane Knopp ,  Winfried Wels

    IPC分类号： C07K16/46 ,  C07K14/705 ,  C07K14/725

    CPC分类号： C07K16/46 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K16/32 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2319/00

    摘要： The present invention relates to multi-functional proteins which comprise (i) a signal peptide, (ii) a target specific recognition domain, (iii) a linker region, connecting domain (ii) and domain (iv) which comprises a specific modified hinge region of the human CD8 alpha-chain, and (iv) an effector domain. The present invention furthermore relates to nucleic acids encoding the proteins, expression constructs for expressing the protein in a host cell and host cells. The proteins of the invention are chimeric antigen receptors with an optimized linker or hinge region that are suitable for generating target-specific effector cells, for use as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy.

    摘要翻译： 本发明涉及多功能蛋白质，其包含（i）信号肽，（ii）靶特异性识别结构域，（iii）连接区，连接结构域（ii）和结构域（iv），其包含特定修饰的铰链 人类CD8α链的区域，和（iv）效应结构域。 本发明还涉及编码蛋白质的核酸，用于在宿主细胞和宿主细胞中表达蛋白质的表达构建体。 本发明的蛋白质是嵌合抗原受体，其具有适于产生靶特异性效应细胞的优化接头或铰链区，用作药物，特别是用于治疗癌症和过继性靶细胞特异性免疫疗法。

    Interleukin 15 as Selectable Marker for Gene Transfer in Lymphocytes
    3.
    发明申请
    Interleukin 15 as Selectable Marker for Gene Transfer in Lymphocytes 有权
    白细胞介素15作为淋巴细胞基因转移的可选标记

    公开(公告)号：US20130280221A1

    公开(公告)日：2013-10-24

    申请号：US13821474

    申请日：2011-09-06

    申请人： Kurt Schonfeld ,  Christiane Knopp ,  Winfried Wels

    发明人： Kurt Schonfeld ,  Christiane Knopp ,  Winfried Wels

    IPC分类号： C12N15/85

    CPC分类号： C07K14/5443 ,  A61K35/17 ,  A61K2035/124 ,  C07K14/7051 ,  C07K14/70517 ,  C07K16/18 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33 ,  C07K2319/74 ,  C12N15/85 ,  C12N15/86 ,  C12N2740/16043

    摘要： The present invention relates to the use of interleukin-15 (IL-15) as selectable marker for gene transfer, preferably of at least one gene of therapeutic interest, into a mammalian cell or cell line, in particular a human cell or cell line. The present invention furthermore relates to transgenic mammalian cells or cell lines expressing IL-15 as selectable marker and co-expressing at least one protein of interest encoded by at least one gene of interest, which is preferably a protein of therapeutic interest. The present invention is in particular suitable for chimeric antigen receptors (CARs) as the gene or protein of interest and their expression in lymphocytes. The transgenic mammalian cells and cell lines are furthermore suitable for use as a medicament, in particular in the treatment of cancer and in immunotherapy, such as adoptive, target-cell specific immunotherapy.

    摘要翻译： 本发明涉及将白细胞介素-15（IL-15）作为选择性标记用于哺乳动物细胞或细胞系，特别是人细胞或细胞系中的基因转移，优选至少一种具有治疗意义的基因的选择性标记。 本发明还涉及表达IL-15作为选择性标记的转基因哺乳动物细胞或细胞系，并共​​同表达由至少一种目的基因编码的至少一种目标蛋白质，其最好是治疗性兴趣的蛋白质。 本发明特别适用于感兴趣的基因或蛋白质的嵌合抗原受体（CAR）及其在淋巴细胞中的表达。 此外，转基因哺乳动物细胞和细胞系适合用作药物，特别是用于治疗癌症和免疫疗法，例如过继性靶细胞特异性免疫疗法。

    Interleukin 15 as selectable marker for gene transfer in lymphocytes
    4.
    发明授权
    Interleukin 15 as selectable marker for gene transfer in lymphocytes 有权
    白细胞介素15作为淋巴细胞基因转移的选择标记

    公开(公告)号：US09487800B2

    公开(公告)日：2016-11-08

    申请号：US13821474

    申请日：2011-09-06

    申请人： Kurt Schonfeld ,  Christiane Knopp ,  Winfried Wels

    发明人： Kurt Schonfeld ,  Christiane Knopp ,  Winfried Wels

    IPC分类号： C12N15/85 ,  C07K14/54 ,  C07K14/725 ,  C07K14/705 ,  C12N15/86 ,  A61K35/12

    CPC分类号： C07K14/5443 ,  A61K35/17 ,  A61K2035/124 ,  C07K14/7051 ,  C07K14/70517 ,  C07K16/18 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33 ,  C07K2319/74 ,  C12N15/85 ,  C12N15/86 ,  C12N2740/16043

    摘要： The present invention relates to the use of interleukin-15 (IL-15) as selectable marker for gene transfer, preferably of at least one gene of therapeutic interest, into a mammalian cell or cell line, in particular a human cell or cell line. The present invention furthermore relates to transgenic mammalian cells or cell lines expressing IL-15 as selectable marker and co-expressing at least one protein of interest encoded by at least one gene of interest, which is preferably a protein of therapeutic interest. The present invention is in particular suitable for chimeric antigen receptors (CARs) as the gene or protein of interest and their expression in lymphocytes. The transgenic mammalian cells and cell lines are furthermore suitable for use as a medicament, in particular in the treatment of cancer and in immunotherapy, such as adoptive, target-cell specific immunotherapy.

    摘要翻译： 本发明涉及将白细胞介素-15（IL-15）作为选择性标记用于哺乳动物细胞或细胞系，特别是人细胞或细胞系中的基因转移，优选至少一种具有治疗意义的基因的选择性标记。 本发明还涉及表达IL-15作为选择性标记的转基因哺乳动物细胞或细胞系，并共​​同表达由至少一种目的基因编码的至少一种目标蛋白质，其最好是治疗性兴趣的蛋白质。 本发明特别适用于感兴趣的基因或蛋白质的嵌合抗原受体（CAR）及其在淋巴细胞中的表达。 此外，转基因哺乳动物细胞和细胞系适合用作药物，特别是用于治疗癌症和免疫疗法，例如过继性靶细胞特异性免疫疗法。

    Chimeric antigen receptors with an optimized hinge region
    5.
    发明授权
    Chimeric antigen receptors with an optimized hinge region 有权
    具有优化铰链区的嵌合抗原受体

    公开(公告)号：US09212229B2

    公开(公告)日：2015-12-15

    申请号：US13821491

    申请日：2011-09-06

    申请人： Kurt Schönfeld ,  Christiane Knopp ,  Winfried Wels

    发明人： Kurt Schönfeld ,  Christiane Knopp ,  Winfried Wels

    IPC分类号： C12N15/63 ,  C07K14/46 ,  C07K16/32 ,  C07K16/46 ,  C07K14/725 ,  C07K14/705

    CPC分类号： C07K16/46 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K16/32 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2319/00

    摘要： The present invention relates to multi-functional proteins which comprise (i) a signal peptide, (ii) a target specific recognition domain, (iii) a linker region, connecting domain (ii) and domain (iv) which comprises a specific modified hinge region of the human CD8 alpha-chain, and (iv) an effector domain. The present invention furthermore relates to nucleic acids encoding the proteins, expression constructs for expressing the protein in a host cell and host cells. The proteins of the invention are chimeric antigen receptors with an optimized linker or hinge region that are suitable for generating target-specific effector cells, for use as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy.

    摘要翻译： 本发明涉及多功能蛋白质，其包含（i）信号肽，（ii）靶特异性识别结构域，（iii）连接区，连接结构域（ii）和结构域（iv），其包含特定修饰的铰链 人类CD8α链的区域，和（iv）效应结构域。 本发明还涉及编码蛋白质的核酸，用于在宿主细胞和宿主细胞中表达蛋白质的表达构建体。 本发明的蛋白质是嵌合抗原受体，其具有适于产生靶特异性效应细胞的优化接头或铰链区，用作药物，特别是用于治疗癌症和过继性靶细胞特异性免疫疗法。

    Nucleic acid transfer system
    6.
    发明授权
    Nucleic acid transfer system 失效
    核酸转运系统

    公开(公告)号：US06498233B1

    公开(公告)日：2002-12-24

    申请号：US08840713

    申请日：1997-04-25

    申请人： Winfried Wels ,  Jesus Fominaya

    发明人： Winfried Wels ,  Jesus Fominaya

    IPC分类号： C07K1900

    CPC分类号： C07K5/1024 ,  A61K38/00 ,  C07K5/1019 ,  C07K14/21 ,  C07K14/39 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/43 ,  C07K2319/55 ,  C07K2319/75 ,  C07K2319/81 ,  C12N15/62 ,  C12N15/87

    摘要： The invention pertains to a nucleic acid transfer system including a translocation domain of toxins, especially of diphtheria toxin suitable for targeting a nucleic acid, e.g. a gene, to a specific cell, and obtaining expression of said nucleic acid. The nucleic acid transfer system of the invention comprises a multidomain protein component and a nucleic acid component. Furthermore, the present invention relates to the multidomain protein, a nucleic acid encoding said protein, suitable amplification and expression systems for said nucleic acid, and processes for the preparation and uses of the above subject matters.

    摘要翻译： 本发明涉及包含毒素易位结构域的核酸转运系统，特别是适于靶向核酸的白喉毒素的易位结构域。 基因，特定细胞，获得所述核酸的表达。 本发明的核酸转移系统​​包含多结构域蛋白质组分和核酸组分。 此外，本发明涉及多结构域蛋白，编码所述蛋白的核酸，所述核酸的合适的扩增和表达系统，以及上述主题的制备和用途的方法。