An endoscopic surgical cutting stapler with a chain articulation is provided, in which a joint is implemented by a chain articulation, teeth are provided at two ends of a chain plate of the chain articulation, and teeth of adjacent chain plates in the same row are engaged. Through mesh transmission of engaged teeth of the adjacent chain plates in the same row, an angle of a most proximal chain plate of the chain articulation is gradually multiplied at several stages and transmitted to an end effector. The end effector can rotate for 90° with small drive motion of the operating mechanism, thereby achieving precise placement of the chain articulation after rotation. The end effector can be precisely aligned with a part to be cut and stapled, and a radius of curvature of the chain articulation can be significantly increased.