发明授权
- 专利标题： Crosslinked hyaluronic acid composition and self-crosslinking hyaluronic acid particles
- 专利标题（中）： 交联透明质酸组合物和自交联透明质酸颗粒
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申请号： US13818848申请日： 2011-08-23
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公开(公告)号： US09216193B2公开(公告)日： 2015-12-22
- 发明人: Masamichi Hashimoto , Tadashi Morikawa , Yoshiaki Miyata , Akio Ohno , Kei Takahashi , Daisuke Ogasawara , Kenji Fujii , Teruaki Kakema , Mariko Takeda
- 申请人： Masamichi Hashimoto , Tadashi Morikawa , Yoshiaki Miyata , Akio Ohno , Kei Takahashi , Daisuke Ogasawara , Kenji Fujii , Teruaki Kakema , Mariko Takeda
- 申请人地址： JP Tokyo
- 专利权人： DENKI KAGAKU KOGYO KABUSHIKI KAISHA
- 当前专利权人： DENKI KAGAKU KOGYO KABUSHIKI KAISHA
- 当前专利权人地址： JP Tokyo
- 代理机构： Oblon, McClelland, Maier & Neustadt, L.L.P.
- 优先权： JP2010-186487 20100823; JP2010-186491 20100823
- 国际申请： PCT/JP2011/068978 WO 20110823
- 国际公布： WO2012/026468 WO 20120301
- 主分类号： A61K31/727
- IPC分类号： A61K31/727 ; A61K31/728 ; C08B37/08 ; C08L5/08 ; A61K8/73 ; A61K9/00
摘要：
The present invention provides a crosslinked hyaluronic acid composition including self-crosslinking hyaluronic acid particles having an equilibrium swelling capacity of 3-fold to 10-fold, and an aqueous solvent, wherein a dry weight of the self-crosslinking hyaluronic acid particles based on the total volume of the crosslinked hyaluronic acid composition is 3 w/v % to 8 w/v %.The crosslinked hyaluronic acid composition of the invention uses self-crosslinking hyaluronic acid particles of which the equilibrium swelling capacity is within the above predetermined range. Accordingly, the viscosity does not sharply increase even if the concentration thereof is increased. Therefore, if the crosslinked hyaluronic acid composition is applied to an injection, it is possible to obtain a sufficient curative effect on knee osteoarthritis even with a small frequency of administration.
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