A hollow syringe barrel for use in syringe mixing systems for mixing a two-component composition. A hollow body of the syringe barrel includes a proximal end, a distal end, and continuous cylindrical wall defining an internal chamber for containing a first component. A rupturable membrane disposed at the distal end caps and seals off a single dispensing orifice. A second syringe barrel can be coupled to the distal end of the hollow syringe barrel to form a syringe-to-syringe mixing system. First and second plungers disposed within the hollow syringe barrel and second syringe barrel, respectively, are used to mix and cycle back and forth first and second components initially contained within the hollow syringe barrel and second syringe barrel. The two components are initially separated by the rupturable membrane, which is irreversibly ruptured by applying sufficient pressure to the first plunger within the hollow syringe barrel prior to mixing.