Invention Grant
- Patent Title: Macrocyclic proline derived HCV serine protease inhibitors
- Patent Title (中): 大环脯氨酸衍生的HCV丝氨酸蛋白酶抑制剂
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Application No.: US14146161Application Date: 2014-01-02
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Publication No.: US09220748B2Publication Date: 2015-12-29
- Inventor: Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
- Applicant: Enanta Pharmaceuticals, Inc.
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Elmore Patent Law Group, P.C.
- Agent Edgar W. Harlan; Carolyn S. Elmore, Esq.
- Main IPC: A61K38/12
- IPC: A61K38/12 ; C07K5/097 ; C07K5/062 ; C07K5/083 ; C07K5/08 ; C07K14/81
Abstract:
The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Public/Granted literature
- US20140194350A1 MACROCYCLIC PROLINE DERIVED HCV SERINE PROTEASE INHIBITORS Public/Granted day:2014-07-10
Information query
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