Invention Grant
US09226899B2 Particulate hyaluronic acid and flavonoid formulations for cellular delivery of bioactive agents
有权
用于细胞递送生物活性剂的颗粒状透明质酸和类黄酮制剂
- Patent Title: Particulate hyaluronic acid and flavonoid formulations for cellular delivery of bioactive agents
- Patent Title (中): 用于细胞递送生物活性剂的颗粒状透明质酸和类黄酮制剂
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Application No.: US14292734Application Date: 2014-05-30
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Publication No.: US09226899B2Publication Date: 2016-01-05
- Inventor: Motoichi Kurisawa , Shengyong Ng , Joo Eun Chung
- Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Applicant Address: SG Singapore
- Assignee: Agency for Science, Technology and Research
- Current Assignee: Agency for Science, Technology and Research
- Current Assignee Address: SG Singapore
- Agency: Blakely, Sokoloff, Taylor & Zafman LLP
- Priority: SG200905341 20090811
- Main IPC: A61K9/50
- IPC: A61K9/50 ; A61K9/16 ; A61K9/10 ; A61K31/353 ; A61K31/7048 ; A61K31/728 ; A61K47/48 ; A61K31/4706 ; A61K38/48 ; C07K16/18

Abstract:
There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.
Public/Granted literature
- US20140271902A1 PARTICULATE HYALURONIC ACID FORMULATIONS FOR CELLULAR DELIVERY OF BIOACTIVE AGENTS Public/Granted day:2014-09-18
Information query