Invention Grant
US09226899B2 Particulate hyaluronic acid and flavonoid formulations for cellular delivery of bioactive agents 有权
用于细胞递送生物活性剂的颗粒状透明质酸和类黄酮制剂

Particulate hyaluronic acid and flavonoid formulations for cellular delivery of bioactive agents
Abstract:
There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.
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