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    Particulate hyaluronic acid and flavonoid formulations for cellular delivery of bioactive agents
    2.
    发明授权
    Particulate hyaluronic acid and flavonoid formulations for cellular delivery of bioactive agents 有权
    用于细胞递送生物活性剂的颗粒状透明质酸和类黄酮制剂

    公开(公告)号：US09226899B2

    公开(公告)日：2016-01-05

    申请号：US14292734

    申请日：2014-05-30

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Motoichi Kurisawa ,  Shengyong Ng ,  Joo Eun Chung

    IPC: A61K9/50 ,  A61K9/16 ,  A61K9/10 ,  A61K31/353 ,  A61K31/7048 ,  A61K31/728 ,  A61K47/48 ,  A61K31/4706 ,  A61K38/48 ,  C07K16/18

    CPC classification number: A61K9/1617 ,  A61K9/10 ,  A61K9/1652 ,  A61K31/353 ,  A61K31/4706 ,  A61K31/7048 ,  A61K31/728 ,  A61K38/482 ,  A61K47/61 ,  C07K16/18 ,  A61K2300/00

    Abstract: There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.

    Abstract translation: 目前提供了在溶液中的不混溶性颗粒的悬浮液，其中颗粒包括生物活性剂，例如抗癌剂的附聚物; 以及多个透明质酸和类黄酮的缀合物，例如儿茶素类黄酮，其中所述颗粒直径平均为约15nm至约300nm，并且其中所述生物活性剂可释放地保留在颗粒中 类黄酮。 悬浮液可用于将生物活性剂递送至细胞，包括癌细胞。 还提供了包含悬浮液的治疗剂型，以及使用悬浮液和治疗剂型的方法，包括将生物活性剂递送至细胞并用于治疗包括癌症的疾病。

    FLAVONOID HYDROGEL
    5.
    发明申请
    FLAVONOID HYDROGEL 有权

    公开(公告)号：US20150313869A1

    公开(公告)日：2015-11-05

    申请号：US14697565

    申请日：2015-04-27

    Applicant: Agency for Science, Technology and Research

    Inventor： Motoichi Kurisawa ,  Fan Lee ,  Joo Eun Chung ,  Pui Yik Peggy Chan

    IPC: A61K31/353 ,  C12P17/06 ,  A61K31/738

    CPC classification number: A61K31/353 ,  A61K9/0024 ,  A61K31/015 ,  A61K31/05 ,  A61K31/738 ,  A61K47/61 ,  A61K47/6903 ,  A61L27/54 ,  C08J3/075 ,  C08J2397/00 ,  C12P17/06 ,  C12P19/26

    Abstract: There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid. There is also provided a method for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid without the addition of an exogenous peroxide or peroxidase or without the addition of an exogenous peroxide. Hydrogels produced by such methods and methods of using the hydrogels are also described herein.

    Abstract translation: 提供了包含水凝胶形成剂和类黄酮的缀合物的水凝胶的方法，包括能够粘附细胞的水凝胶的制造方法，其包含水凝胶形成剂和类黄酮的酶交联的缀合物。 还提供了一种制备水凝胶的方法，其包括水凝胶形成剂和类黄酮的缀合物，而不加入外源性过氧化物酶或过氧化物酶或不加入外源过氧化物。 本文还描述了通过这些使用水凝胶的方法和方法生产的水凝胶。

    Green Tea-based Nanocomplexes for Eye Disease
    6.
    发明申请
    Green Tea-based Nanocomplexes for Eye Disease 有权

    公开(公告)号：US20240390503A1

    公开(公告)日：2024-11-28

    申请号：US18690862

    申请日：2022-08-31

    Applicant: Agency for Science, Technology and Research ,  Singapore Health Services Pte Ltd

    Inventor： Motoichi Kurisawa ,  Nunnarpas Yongvongsoontorn ,  Joo Eun Chung ,  Yasuo Yanagi

    IPC: A61K47/54 ,  A61K9/00 ,  A61K47/61 ,  A61K47/69 ,  A61P27/02

    Abstract: The present invention relates to a composition comprising a self-assembled nanocomplex, wherein the self-assembled nanocomplex comprises one or more active agent physically bound to one or more conjugate, wherein each conjugate comprises one or more flavonoid molecule and a first water-soluble polymer, and the nanocomplex is at least partially encapsulated by a second water-soluble polymer. The present invention also relates to a method of preparing the composition and uses thereof. The present invention also relates to a method of treating an eye disease caused by angiogenesis, comprising administering a composition to a subject in need thereof, wherein the composition comprises a self-assembled nanocomplex, wherein the self-assembled nanocomplex comprises an ophthalmic anti-angiogenesis drug physically bound to one or more conjugate, each conjugate comprising one or more flavonoid molecule and a first water-soluble polymer.

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