Invention Grant
US09227942B2 Method for producing 5-(difluoromethyl)pyrazine-2-carboxylic acid and production intermediate thereof
有权
5-（二氟甲基）吡嗪-2-羧酸的制备方法及其制备中间体
- Patent Title: Method for producing 5-(difluoromethyl)pyrazine-2-carboxylic acid and production intermediate thereof
- Patent Title (中): 5-（二氟甲基）吡嗪-2-羧酸的制备方法及其制备中间体
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Application No.: US14396261Application Date: 2013-04-25
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Publication No.: US09227942B2Publication Date: 2016-01-05
- Inventor: Kazuhiro Yoshizawa , Masayuki Omori , Yuzo Watanabe , Mitsuo Nagai , Masabumi Takahashi , Francis G. Fang
- Applicant: Eisai R&D Management Co., Ltd.
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- International Application: PCT/JP2013/062863 WO 20130425
- International Announcement: WO2013/162065 WO 20131031
- Main IPC: C07D241/24
- IPC: C07D241/24
Abstract:
5-(Difluoromethyl)pyrazine-2-carboxylic acid, which is a raw material for the construction of 5-(difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an Aβ production inhibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5-[carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate.
Public/Granted literature
- US20150087836A1 METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF Public/Granted day:2015-03-26
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