-
公开(公告)号：US20220194925A1
公开(公告)日：2022-06-23
申请号：US17604527
申请日：2020-05-13
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Taichi Abe , Kazuhiro Yoshizawa , Yuzo Watanabe , Takeshi Miura , Yusuke Ayata , Yoshinori Yasuda
IPC: C07D401/12 , C07C41/09 , C07D239/34
Abstract: The present application discloses a method and a compound that are useful for preparation of a compound of Formula (XI). Furthermore, the present application discloses the compound of Formula (XI) comprising a small amount of impurities.
-
2.发明授权Method for producing 5-(difluoromethyl)pyrazine-2-carboxylic acid and production intermediate thereof 有权5-（二氟甲基）吡嗪-2-羧酸的制备方法及其制备中间体公开(公告)号：US09227942B2
公开(公告)日：2016-01-05
申请号：US14396261
申请日：2013-04-25
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Kazuhiro Yoshizawa , Masayuki Omori , Yuzo Watanabe , Mitsuo Nagai , Masabumi Takahashi , Francis G. Fang
IPC: C07D241/24
CPC classification number: C07D241/24
Abstract: 5-(Difluoromethyl)pyrazine-2-carboxylic acid, which is a raw material for the construction of 5-(difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an Aβ production inhibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5-[carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate.
Abstract translation: 5-（二氟甲基）吡嗪-2-甲酸，其是用于构建具有A＆bgr的化合物的常见部分结构基序的5-（二氟甲基）吡嗪-2-甲酰胺的原料。 产生抑制作用或BACE1抑制作用，可在工业上有利地由5-氯吡嗪-2-羧酸酯得到5- [羧基（二氟）甲基]吡嗪-2-羧酸脱羧产生。
-
3.发明申请METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF 有权生产5-（二氟甲基）吡唑-2-羧酸的方法及其中间体的制备方法公开(公告)号：US20150087836A1
公开(公告)日：2015-03-26
申请号：US14396261
申请日：2013-04-25
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Kazuhiro Yoshizawa , Masayuki Omori , Yuzo Watanabe , Mitsuo Nagai , Masabumi Takahashi , Francis G. Fang
IPC: C07D241/24
CPC classification number: C07D241/24
Abstract: 5-(Difluoromethyl)pyrazine-2-carboxilic acid, which is a raw material for the construction of 5-(difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an A production inhibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5-[carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate.
Abstract translation: 5-（二氟甲基）吡嗪-2-甲酸，其是用于构建5-（二氟甲基）吡嗪-2-甲酰胺的原料，其是具有A产生抑制作用的化合物的常见部分结构基序或 BACE1抑制作用可以在工业上有利地由5-氯吡嗪-2-羧酸酯可得5- [羧基（二氟）甲基]吡嗪-2-羧酸脱羧制得。
-
-
Search Results
3
records
(took 0.011 seconds)
